Heikki Savolainen, Ministry of Social Affairs and Health
4 July 2012
Dear Editor,
Ling et al. (1) show convincingly that highly oxygen-depedent organs are more prone to the toxic effects of D-lactate than liver.
However, dosing of D-lactate in a liver cell culture has other very interesting effects. Namely, the PI3K/AktPKB/PKC acitivity is decreased which leads to low BAD activity allowing increased apoptosis (2).
This indicates that D-lactate can also have other significant metabolic effects e.g. in diabetics who have increased D-lactate burden because of excessive methylglyoxal from glucose (3).
Complex effects of D-lactate
4 July 2012
Dear Editor,
Ling et al. (1) show convincingly that highly oxygen-depedent organs are more prone to the toxic effects of D-lactate than liver.
However, dosing of D-lactate in a liver cell culture has other very interesting effects. Namely, the PI3K/AktPKB/PKC acitivity is decreased which leads to low BAD activity allowing increased apoptosis (2).
This indicates that D-lactate can also have other significant metabolic effects e.g. in diabetics who have increased D-lactate burden because of excessive methylglyoxal from glucose (3).
1 Ling et al. Nutrition and Metab 2012; 9: 6
2 Miyamato. J Am Coll Surg 2007; 204: 182
3 Talasniemi et al. Clin Biochem 2008; 41: 1099
Competing interests
None