Figure 3From: Uric acid: A new look at an old risk marker for cardiovascular disease, metabolic syndrome, and type 2 diabetes mellitus: The urate redox shuttleAntioxidant – prooxidant urate redox shuttle. The antioxidant – prooxidant urate redox shuttle is an important concept to understand regarding accelerated atherosclerosis. This shuttle is important in understanding the role of how the antioxidant uric acid becomes prooxidant in this environmental milieu, which results in its damaging role to the endothelium and arterial vessel wall remodeling with an elevated tension of oxidative – redox stress (ROS), accelerated atherosclerosis and arterial vessel wall remodeling.Back to article page