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Table 1 A-FLIGHT-U ACRONYM Identification of multiple metabolic toxicities and injurious stimuli responsible for reactive oxygen species production. (figure 2)

From: Uric acid: A new look at an old risk marker for cardiovascular disease, metabolic syndrome, and type 2 diabetes mellitus: The urate redox shuttle

A Angiotensin II (also induces PKC-β isoform)
Amylin (hyperamylinemia) / amyloid toxicity
AGEs/AFEs (advanced glycosylation/fructosylation endproducts)
Apolipoprotein B
Antioxidant reserve compromised
Absence of antioxidant network
Aging
ADMA (Asymmetrical DiMethyl Arginine)
F Free fatty acid toxicity: Obesity toxicity: Triad
L Lipotoxicity – Hyperlipidemia – Obesity toxicity: Triad
I Insulin toxicity (endogenous hyperinsulinemia-hyperproinsulinemia)
Inflammation toxicity
G Glucotoxicity (compounds peripheral insulin resistance) reductive stress
Sorbitol/polyol pathway
Pseudohypoxia (increased NADH/NAD ratio)
H Hypertension toxicity
Homocysteine toxicity
hs-CRP
T Triglyceride toxicity: Obesity toxicity: Triad
U Uric Acid toxicity: Antioxidant early in physiological range and a conditional prooxidant late when elevated through the paradoxical (antioxidant → prooxidant)
  URATE REDOX SHUTTLE
  Endothelial cell dysfunction with eNOS uncoupling, decreased eNO and increased ROS.
  Vulnerable atherosclerotic plaque milieu of being acidic, proinflammatory, excess metal ions (Fe) (Cu) from vasa vasorum rupture and red blood cell plasma membranes due to intraplaque hemorrhage and plaque thrombus formation.