Management of multifactorial idiopathic epilepsy in EL mice with caloric restriction and the ketogenic diet: role of glucose and ketone bodies

Table 3 Binary logistic regression analysis of the maximum likelihood estimates between plasma glucose, and seizure susceptibility in adult EL mice fed either the SD or KD¹

Dietary groups	Parameter	Df²	B³	SEM⁴	Wald x^{2 5}	p value⁶
SD	Glucose	1	0.774	0.139	30.962	0.01
	Constant	1	-0.584	1.013	29.292	0.01
KD	Glucose	1	0.787	0.157	25.033	0.01
	Constant	1	-5.801	1.180	24.177	0.01
Both Diets	Glucose	1	0.752	0.102	54.682	0.01
	Constant	1	-5.507	0.759	52.625	0.01

¹ Data were obtained from all four dietary groups over the treatment weeks 3–12 for a total number of 210 individual measurements of plasma glucose and seizure susceptibility.
² Df, degrees of freedom.
³ B, Estimate of the association between glucose and seizure susceptibility.
⁴ The estimated error of the mathematical weighting, indicating the precision of the estimated coefficient.
⁵ The Wald test statistic was computed from the data compared by using x² distribution with 1 degree of freedom. The test statistic is used to determine the p value.
⁶ The probability of Type I error.