β3-adrenoceptor agonist prevents alterations of muscle diacylglycerol and adipose tissue phospholipids induced by a cafeteria diet

Christian Darimont; Marco Turini; Micheline Epitaux; Irène Zbinden; Myriam Richelle; Eulàlia Montell; Andreu Ferrer-Martinez; Katherine Macé

doi:10.1186/1743-7075-1-4

Table 5 Composition of muscle lipids

From: β3-adrenoceptor agonist prevents alterations of muscle diacylglycerol and adipose tissue phospholipids induced by a cafeteria diet

% mole fatty acids	REF	CAF	CAF-ZD
Phospholipids
Palmitic acid (16:0)	27.87 ± 0.50	26.17 ± 0.29	26.44 ± 0.57
Stearic acid (18:0)	20.21 ± 0.64	22.37 ± 0.54 *	21.64 ± 0.58
Oleic acid (18:1n-9)	6.84 ± 0.21	9.13 ± 0.48 **	9.12 ± 0.24 **
Linoleic acid (18:2n-6)	13.09 ± 0.65	8.98 ± 0.51**	9.02 ± 0.28 **
Arachidonic acid (20:4n-6)	11.64 ± 0.46	15.07 ± 0.53**	14.11 ± 0.22 **
Docosatetraenoic acid (22:4n-6)	ND	0.61 ± 0.04	0.51 ± 0.02
Adrenic acid (22:5n-3)	2.04 ± 0.07	2.44 ± 0.18	2.10 ± 0.09
Docosahexaenoic acid (22:6n-3)	18.30 ± 0.95	15.23 ± 0.52 *	16.09 ± 0.35
Triacylglycerol
Myristic acid (14:0)	ND	1.66 ± 0.08	1.53 ± 0.06
Palmitic acid (16:0)	37.13 ± 2.06	25.26 ± 0.95 **	25.15 ± 0.81 **
Stearic acid (18:0)	7.94 ± 0.31	9.36 ± 0.45 *	9.38 ± 0.65
Palmitoleic acid (16:1n-7)	ND	1.51 ± 0.14	1.31 ± 0.13
Oleic acid (18:1n-9)	29.00 ± 0.94	51.36 ± 1.83 **	50.14 ± 0.93 **
Linoleic acid (18:2n-6)	25.00 ± 1.98	10.86 ± 0.83 **	12.47 ± 0.66 **
Diacylglycerol
Myristic acid (14:0)	1.92 ± 0.09	1.75 ± 0.07	1.85 ± 0.05
Palmitic acid (16:0)	25.55 ± 0.86	22.42 ± 1.22	24.88 ± 0.62
Stearic acid (18:0)	6.71 ± 0.45	8.74 ± 0.63 *	9.71 ± 0.08 **
Palmitoleic acid (16:1n-7)	2.58 ± 0.20	1.59 ± 0.14 **	1.26 ± 0.07 **
Oleic acid (18:1n-9)	28.90 ± 1.24	52.88 ± 1.25 **	46.45 ± 1.61 ** ++
Nervonic acid (24:1n-9)	3.92 ± 1.93	1.24 ± 0.42	2.71 ± 0.88
Linoleic acid (18:2n-6)	26.96 ± 2.22	10.14 ± 2.04 **	8.05 ± 0.69 **
α-linolenic acid (18:3n-3)	1.12 ± 0.18	ND	ND
Stearidonic acid (18:4n-3)	ND	ND	1.90 ± 0.41
Arachidonic acid (20:4n-6)	0.78 ± 0.06	0.46 ± 0.06 **	0.26 ± 0.04 ** +

Data are the mean ± SEM. Values significantly different from those obtained in the group of rats fed a chow diet (REF) are indicated by * (p < 0.05) and ** (p < 0.01). Data measured in the group of rats treated with ZD7114 (CAF-ZD) and significantly different from those in the group of rats fed a cafeteria diet (CAF) are shown by + (p < 0.05) and ++ (p < 0.05). Fatty acids representing more than 1% in at least one group are presented.

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