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Figure 1 | Nutrition & Metabolism

Figure 1

From: Folic acid and melatonin ameliorate carbon tetrachloride-induced hepatic injury, oxidative stress and inflammation in rats

Figure 1

Photomicrographs for liver sections of the different groups A: Photomicrograph of a control liver section showing the normal histological architecture of hepatic tissues (H&E stain, 400x). B: The histological features of a representative liver section from CCl4-treated rats (the sections from four rats in this group were investigated), which shows the increased number of mitotic figures (arrow) and the clear vacuolation of the hepatocytes (H&E stain, 1000x). Insert: In addition to the mitotic figures, eosinophilic hepatocytes (arrow) were detected in sections from two of the CCl4-treated rats in this group (H&E stain, 400x). C: A representative liver section from CCl4 + Me-treated rats (H&E stain, 400x) was characterized by the absence of the mitotic figures. However, vacuolated hepatocytes and abnormal damaged hepatic tissues were still found. D: A representative liver section from CCl4 + Fo-treated rats shows many mitotic figures (white arrows), which resemble those detected in the liver sections from CCl4-treated rats. A number of pyknotic nuclei were detected in the sections from this group (H&E stain, 400x). E: A representative liver section from CCl4 + Me + Fo-treated rats, which exhibit an improvement of the general hepatic architecture (sections from five rats in this group were investigated) (H&E stain, 400x). F: A liver section from the group of CCl4 + Me + Fo-treated rats that shows little improvement (this was observed in the sections from two of the rats) (H&E stain, 400x). G: A representative liver section from Fo-treated rats, which shows the general hepatic architecture with a small amount of side effects, such as faintly stained nuclei (H&E stain, 400x). H: A representative liver section from Me-treated rats, which shows the general hepatic architecture with narrow hepatic sinusoids and a large number of hepatocytes (H&E stain, 400x).

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