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Table 2 Concentrations of oxidative stress parameters and relative mRNA expression of TNF-α, AKT1, Fas and IFN-γ induced in the different groups

From: Folic acid and melatonin ameliorate carbon tetrachloride-induced hepatic injury, oxidative stress and inflammation in rats

Parameters Control group CCL4 Me CCL4+Me Fo CCL4+Fo CCL4+Me + Fo
Blood Hydroperoxide (mg/100 ml) 24 ± 5.0 44.5* ± 6.2 21.5 ± 4.3 32.1* ± 4.2 21.8 ± 3.0 30.6 ± 6.3 27 ± 5.0
Hepatic MDA (nmol/mg protein) 3 ± 0.7 5.6* ± 0.9 2.1 ± 0.8 4* ± 0.7 2.4 ± 0.7 4.4* ± 0.9 2.1 ± 0.6
Hepatic GSH (μmol/g liver tissue) 12.2 ± 1.8 5* ± 1.8 25.7* ± 7.8 14.7 ± 5.0 28.6* ± 5.8 21.7* ± 5.0 21.2* ± 5.1
Catalase (Unit/mg protein) 14.4 ± 1.8 7.9* ± 1.0 16.3 ± 1.8 11.5 ± 2.8 16 ± 2.7 10* ± 0.9 14 ± 1.5
Relative expression of TNF-α mRNA 1.8 ± 0.8 5.6* ± 0.9 1.6 ± 0.5 3.3* ± 0.7 2.1 ± 0.8 3.2* ± 0.7 1.7 ± 0.5
Relative expression of Akt1 mRNA 5.7 ± 1.1 1.8* ± 0.5 15.2* ± 2.7 5.0 ± 1.3 17* ± 1.8 5.0 ± 1.6 7.0 ± 1.8
Relative expression of Fas mRNA 0.9 ± 0.3 10.1* ± 0.9 0.8 ± 0.45 8.2* ± 1.2 0.78 ± 0.2 5.5* ± 0.2 2.5* ± 0.7
Relative expression of IFN- γ mRNA 18.5 ± 7.2 7.0* ± 2.2 17.5 ± 6.0 8.8* ± 0.9 34.2* ± 4.4 14.6 ± 2.6 20.2 ± 3.0
  1. The results are expressed as M ± SD. * shows a statistically significant difference (P < 0.05) in the pairwise comparison between a treatment group and the control.