Table 2 Baseline and 3 months plasma antioxidants and markers of oxidative damage in the intervention group compared with the placebo group (mean SD)
Placebo | Supplement | B (95% C.I) + | P value* | ||
|---|---|---|---|---|---|
(n = 50) | (n = 50) | ||||
Vitamin C (mg/l) | Baseline | 23.8 (16.8) | 33.00 (20.1) | ||
3 months | 19.5 (12.1) | 18.9 (12.8) | −0.3 (−6.5, 5.8) | 0.913 | |
Vitamin E (mg/l) | baseline | 7.3 (4.5) | 8.6 (3.2) | ||
3 months | 7.6 (4.6) | 11.4 (4.5) | 3.1 (0.9, 5.3) | 0.006 | |
Vitamin A (mg/l) | Baseline | 0.578 (0.29) | 0.797 (0.34) | ||
3 months | 0.624 (0.39) | 0.844 (0.29) | 0.1(−0.12, 0.22) | 0.541 | |
Glutathione(nM/ml) | Baseline | 0.231 (0.27) | 0.245 (0.31) | ||
3 months | 0.139 (0.13) | 0.169 (0.15) | 0.03 (−0.04, 0.10) | 0.346 | |
Folate (nmol/l) | baseline | 18.2 (8.9) | 18.95 ((8.1) | ||
3 months | 18.7 (8.6) | 32.4 (11.9) | 13.5 (9.7, 17.4) | 0.001 | |
B12 (pmol/l) | Baseline | 236 (103) | 179 (93) | ||
3 months | 227 (99) | 252 (191) | 93 (48, 139) | 0.001 | |
Homocysteine | Baseline | 10.3 (3.2) | 12.7 (4.5) | ||
(mmol/l) | 3 months | 10.7 (3.3) | 11.5 (3.3) | −0.33 (−1.8, 1.2) | 0.657 |
Protein carbonyl | baseline | 0.797 (0.28) | 0.456 (0.46) | ||
(nmol/mg) | 3 months | 1.080 (0.46) | 0.737 (0.35) | −0.34 (−0.56, -0.13 | 0.002 |
MDA (nM/ml) | Baseline | 16.7 (15.8) | 6.1 (8.9) | ||
3 months | 18.5 (9.9) | 19.7 (11.2) | −0.64 (−5.96, 4.67) | 0.810 |