Table 3 Impact of the SNP, RBCs total n-3 PUFA and the interaction SNP * RBCs total n-3 PUFA on plasma lipids and lipoproteins levels

Total cholesterol (TC)

AGT

0.1453

0.4455

C/C (71%)

0^a

0.0448

M235T

C/T (26%)

0.0210 ± 0.0262^a

rs699*

T/T (3%)

−0.1482 ± 0.0651^b

CETP

0.0152

<0.0001

C/C (36%)

0^a

0.0326

C-4502T

C/T (49%)

−0.0632 ± 0.0241^b

rs183130

T/T (15%)

−0.0421 ± 0.0343^ab

CETP

0.1115

0.0002

C/C (26%)

0^ab

0.0334

Ile405Val

C/T (47%)

0.0397 ± 0.0268^a

rs5882*

T/T (26%)

−0.0290 ± 0.0307^b

LDL-Cholesterol (LDL-C)

AGT

0.1514

0.6339

C/C (71%)

0^a

0.0405

M235T

C/T (26%)

0.0299 ± 0.0238 ^a

rs699*

T/T (3%)

−0.1228 ± 0.0592^b

APOA5

0.012

0.0018

A/A (42%)

0^a

0.006

−3 A/G

G/A (45%)

0.0678 ± 0.0213^b

rs651821

G/G (13%)

0.0474 ± 0.0332^ab

APOA5

0.0137

0.0035

T/T (42%)

0^a

0.0072

T-1131C

T/C (44%)

0.0669 ± 0.0213^b

rs662799

C/C (34%)

0.0427 ± 0.0339^ab

HDL-Cholesterol (HDL-C)

APOA5

0.126

0.0002

A/A (42%)

0^a

0.0065

−3 A/G

G/A (45%)

−0.0317 ± 0.0100^b

rs651821

G/G (13%)

−0.0105 ± 0.0155^ab

APOA5

0.01476

0.0002

T/T (42%)

0^a

0.0072

T-1131C

T/C (44%)

−0.0314 ± 0.0100^b

rs662799

C/C (34%)

−0.0115 ± 0.0159^ab

CEPT

0.2302

0.0017

C/C (26%)

0^a

0.0271

Ile405Val

C/T (47%)

0.0263 ± 0.0115^b

rs5882*

T/T (26%)

0.0017 ± 0.0131^a

Triglycerides (TG)

CETP

0.0092

0.3779

C/C (36%)

0^ab

0.0300

C-4502T

T/C (49%)

−0.0095 ± 0.0051^a

rs183130

T/T (15%)

0.0073 ± 0.0073^b

CETP

0.0087

0.399

G/G (28%)

0^ab

0.0032

G-971A

A/G (50%)

−0.0106 ± 0.0057^a

rs4783961

A/A (22%)

0.0087 ± 0.0068^b

Ratio Total Cholesterol/ HDL-Cholesterol

APOC3

0.2263

0.7503

C/C (33%)

0^a

0.0137

SstI

C/G (46%)

0.0081 ± 0.0030 ^b

rs5128*

G/G (21%)

0.0085 ± 0.0039 ^b

APOA5

0.0016

0.5195

A/A (42%)

0^a

<0.0001

−3 A/G

G/A (45%)

0.0128 ± 0.0028 ^b

rs651821

G/G (13%)

0.0053 ± 0.0044^ab

APOA5

0.0018

0.62

T/T (42%)

0^a

<0.0001

T-1131C

T/C (44%)

0.0126 ± 0.0028^b

rs662799

C/C (14%)

0.0050 ± 0.0045^ab

CETP

0.188

0.8473

G/G (28%)

0^ab

0.0483

G-971A

A/G (50%)

−0.0055 ± 0.0033^a

rs4783961

A/A (22%)

0.0022 ± 0.0039^b

ApoB100

APOC3

0.0374

0.0399

C/C (33%)

0^a

0.0073

SstI

C/G (46%)

0.0179 ± 0.0058 ^b

rs5128*

G/G (21%)

0.0145 ± 0.0076 ^ab

APOA4

0.0277

0.0221

A/A (33%)

0^a

0.0052

Asn147Ser

A/G (45%)

0.0178 ± 0.0058^b

rs5104

G/G (22%)

0.0177 ± 0.0073^b

APOA5

0.0006

0.091

A/A (42%)

0^a

0.0002

−3 A/G

G/A (45%)

0.0229 ± 0.0055^b

rs651821

G/G (13%)

0.0086 ± 0.0086^ab

APOA5

0.0009

0.0516

T/T (42%)

0^a

0.0002

T-1131C

T/C (44%)

0.0227 ± 0.0055^b

rs662799

C/C (34%)

0.0117 ± 0.0088^ab