Effect of CR and spice compounds on LPS-stimulated PGE
production. Spleen cells were stimulated with LPS for 24 h and supernatant was used to determine PGE2 production using a MSD kit and platform. Values are means ± SEM (n = 6 mice/group). Means without a common letter differ at P < 0.05. HFD: high fat diet, CR: caloric restriction, C: curcumin, P: piperine.