Deregulation of insulin-signaling pathway genes in C. elegans klf-3 ( ok1975 ) mutant. The level of genes (designated at bottom) was measured by real-time PCR. Lines at top of each bar represent standard error of the measurement. Abundance of individual gene is expressed as relative to wild-type at scale “1”. The bar above “1” represent up-regulated, while the bars below “1” represent down-regulated genes.