Figure 6
From: Fructose-induced stress signaling in the liver involves methylglyoxal
Effects of N-acetyl cysteine on fructose- and methylglyoxal- mediated stress and insulin signaling in primary hepatocytes. Methylglyoxal concentration (A), phosphorylation of MKK7 and JNK (B), and tyrosine phosphorylation of IRS-1 and IRS-2 (C) in primary hepatocytes incubated in the presence of fructose delivery (GF) or methylglyoxal in the media (MG) in the absence (No Additions) or presence of NAC (20 uM). Data in graphs are the mean ± SDEV for 4 independent experiments performed in triplicate. * significantly different from No Additions (p < 0.05).