Circulating glucagon-like peptide-1 increases in response to short-term overfeeding in men

Nutrition & Metabolism

Table 1 Physical and biochemical characteristics of subjects at baseline and in response to 7-days of overfeeding ^a,b

	Entire cohort (n = 72)
	Day 1	Day 8	*p-value*	Change (Δ) from baseline	Average percent change from baseline (%)
Age	23.11 ± 0.37	N/A	-	N/A	N/A
Height (cm)	179.18 ± 0.72	N/A	-	N/A	N/A
Weight (kg)^b	80.92 ± 1.81	83.13 ± 1.87	<0.001	2.21 ± 0.16	2.74 ± 0.20
BMI (kg/m²)^b	25.27 ± 0.56	25.96 ± 0.58	<0.001	0.69 ± 0.05	2.74 ± 0.20
Percent body fat	22.41 ± 1.05	22.69 ± 1.00	0.051	0.28 ± 0.14	2.65 ± 0.87
Percent trunk fat	25.15 ± 1.17	25.52 ± 1.10	0.088	0.38 ± 0.21	3.25 ± 1.10
Percent android fat^b	28.64 ± 1.38	29.44 ± 1.35	<0.001	0.80 ± 0.21	4.77 ± 1.37
Percent gynoid fat	27.27 ± 1.03	27.50 ± 0.99	0.221	0.23 ± 0.19	1.80 ± 0.89
Total cholesterol (mmol/L)^b	4.50 ± 0.10	4.74 ± 0.10	0.007	0.23 ± 0.08	6.33 ± 1.88
HDL cholesterol (mmol/L)^b	1.31 ± 0.03	1.41 ± 0.03	<0.001	0.10 ± 0.02	9.08 ± 1.88
Total cholesterol:HDLc ratio^b	3.58 ± 0.10	3.47 ± 0.10	0.020	−0.10 ± 0.04	−2.11 ± 1.12
LDL cholesterol (mmol/L)	2.72 ± 0.08	2.75 ± 0.08	0.639	0.03 ± 0.06	2.88 ± 2.17
Triacylglycerols (mmol/L)^b	1.08 ± 0.06	1.44 ± 0.16	0.005	0.35 ± 0.15	44.74 ± 21.54
Glucose (mmol/L)	5.10 ± 0.06	5.11 ± 0.06	0.905	0.01 ± 0.07	0.75 ± 1.31
Insulin (pmol/L)^b	68.54 ± 8.27	86.84 ± 7.78	<0.001	18.29 ± 6.98	55.02 ± 9.53
HOMA-IR^b	2.38 ± 0.34	2.92 ± 0.29	<0.001	0.54 ± 0.29	59.71 ± 10.77
HOMA-β^b	114.57 ± 8.85	158.38 ± 12.38	<0.001	43.80 ± 9.30	50.60 ± 8.01
Serum GLP-1 (pmol/L)^b	36.84 ± 3.16	42.39 ± 3.18	<0.001	5.55 ± 1.57	24.10 ± 5.85

^a Values are mean ± SE. Homeostasis model assessment of insulin resistance (HOMA-IR) and of B cell function (HOMA-β); GLP-1, Glucagon-like Peptide-1; N/A, not applicable.
^b Significant difference present between pre- and post- overfeeding (paired t-test; SPSS 19.0).

ISSN: 1743-7075