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Table 1 Correlations between plasma PCSK9 and metabolic parameters

From: Plasma PCSK9 concentrations during an oral fat load and after short term high-fat, high-fat high-protein and high-fructose diets

correlation with PCSK9

CTRL

HFruc1

Rho de Spearman

p-value

n

Rho de Spearman

p-value

n

FPG (mg/dl)

−0,040

0,859

22

0,266

0,232

22

GIR (1st)

−0,084

0,710

22

−0,593

0,004

22

GIR (2nd)

0,045

0,844

22

−0,439

0,041

22

HGP

−0,189

0,412

22

−0,019

0,934

22

HGP (1st)

0,003

0,991

22

0,542

0,009

22

HGP (2nd)

−0,143

0,526

22

0,116

0,608

22

FFA (mmol/l)

−0,317

0,150

22

−0,054

0,811

22

IHCL

0,182

0,417

22

0,558

0,007

22

IMCL

0,381

0,080

22

0,195

0,385

22

CT(mg/dl)

0,095

0,673

22

0,364

0,096

22

LDL-C (mg/dl)

0,178

0,427

22

0,344

0,117

22

TG (mg/dl)

0,267

0,230

22

0,538

0,010

22

VLDL-TG (mg/dl)

0,341

0,120

22

0,608

0,003

22

HDL-C (mg/dl)

−0,343

0,118

22

0,006

0,980

22

  1. Spearman’s correlations between plasma PCSK9 levels and metabolic parameters in healthy volunteers (n=7) and offsprings of type 2 diabetic patients (n=15) after an isocaloric control (CTRL) or a high fructose (HFruc1) diet[24]. Data from both groups of patients were pooled to increase statistical power. GIR: glucose infusion rate, HGP: hepatic glucose production, IHCL: intrahepatocellular lipid content, IMCL: intramyocellular lipid content, FPG: fasting plasma glucose, 1st indicates the first step (0.3 mU.kg-1.min-1) and 2st the second step (1.0 mU.kg-1.min-1) of the hyperinsulinemic-euglycemic clamp.