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Table 1 Body characteristics and biochemical, lipid and hormone profile of experimental subjects

From: Prediabetic changes in gene expression induced by aspartame and monosodium glutamate in Trans fat-fed C57Bl/6 J mice

  TFA MSG + TFA ASP + TFA ASP + MSG + TFA Sig.
Body Weight (g)      
  6-week 20.07 ± 0.43 21.29 ± 0.28 20.94 ± 0.26 21.03 ± 0.32 0.06
  17-week 31.58 ± 0.77 32.99 ± 0.59 31.37 ± 0.58 32.36 ± 0.87 0.31
% Weight Change 57.58 ± 2.85 54.91 ± 1.59 50.19 ± 3.44 54.78 ± 2.38 0.27
Adipose Weight (g) 1.08a ± 0.13 1.36ab ± 0.09 0.98a ± 0.16 1.67b ± 0.14 0.001
Liver Weight (g) 1.25 ± 0.06 1.23 ± 0.05 1.30 ± 0.03 1.33 ± 0.06 0.49
Liver Triglyceride (mg/ml) 8.12a ± 0.65 12.14b ± 1.00 9.90ab ± 1.16 13.33b ± 0.84 0.001
T_CHOL (mmol/dL) 121.60a ± 1.34 121.67a ± 3.25 127.0ab ± 1.62 130.13b ± 1.54 0.01
HDL (mmol/dL) 87.43 ± 4.08 89.39 ± 4.61 96.75 ± 1.22 98.09 ± 2.91 0.08
Free Fatty Acids (μM) 156.99ab ± 4.59 177.36bc ± 7.73 146.2a ± 5.30 190.03c ± 5.36 <0.0001
Fasting Glucose (mg/dL)      
  6-week 45.00a ± 2.10 52.03ab ± 3.41 62.50b ± 3.09 92.50c ± 3.87 <0.0001
  17-week 98.53ac ± 8.05 117.43ab ± 10.21 81.97c ± 6.53 132.90b ± 8.23 <0.001
Insulin (pg/ml) 525.5 ± 55.6 552.51 ± 56.57 539.73 ± 43.84 606.46 ± 54.50 0.75
HOMA-IR 3.65a ± 0.38 4.67ab ± 0.27 3.06a ± 0.31 5.86b ± 0.70 <0.001
C-Peptide (pg/ml) 1761.88a ± 200.3 1708.5a ± 123.17 1078.42b ± 86.51 1994.65a ± 150.65 <0.001
Amylin (pg/ml) 58.38 ± 5.39 58.82 ± 5.55 64.74 ± 4.24 59.75 ± 4.82 0.81
GIP (pg/ml) 129.13ab ± 17.9 95.46b ± 7.37 143.68c ± 11.91 113.75ac ± 8.69 0.04
Leptin (pg/ml) 5096.68a ± 662.7 9073.34b ± 1319.8 5460.9a ± 979.17 10917.55b ± 716.01 <0.001
MCP-1 (pg/ml) 69.06a ± 7.26 55.09a ± 6.03 69.05a ± 7.96 39.58b ± 4.53 0.01
Resistin (ng/ml) 25.24 ± 1.64 23.12 ± 1.33 21.64 ± 1.24 25.33 ± 1.67 0.26
TNF-α (pg/ml) 11.35a ± 1.35 7.77a ± 1.97 9.59a ± 1.40 30.56b ± 11.44 0.03
  1. HOMA-IR Homeostasis model of assessment of insulin resistance, GIP Gastric inhibitory polypeptide, MCP-1 Monocyte chemotactic peptide-1. Data are presented as Means ± SEM (n = 15 per diet group). Significant differences in Means are indicated using different letters abc for p-value of <0.05.