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Table 1 Body characteristics and biochemical, lipid and hormone profile of experimental subjects

From: Prediabetic changes in gene expression induced by aspartame and monosodium glutamate in Trans fat-fed C57Bl/6 J mice

 

TFA

MSG + TFA

ASP + TFA

ASP + MSG + TFA

Sig.

Body Weight (g)

     

  6-week

20.07 ± 0.43

21.29 ± 0.28

20.94 ± 0.26

21.03 ± 0.32

0.06

  17-week

31.58 ± 0.77

32.99 ± 0.59

31.37 ± 0.58

32.36 ± 0.87

0.31

% Weight Change

57.58 ± 2.85

54.91 ± 1.59

50.19 ± 3.44

54.78 ± 2.38

0.27

Adipose Weight (g)

1.08a ± 0.13

1.36ab ± 0.09

0.98a ± 0.16

1.67b ± 0.14

0.001

Liver Weight (g)

1.25 ± 0.06

1.23 ± 0.05

1.30 ± 0.03

1.33 ± 0.06

0.49

Liver Triglyceride (mg/ml)

8.12a ± 0.65

12.14b ± 1.00

9.90ab ± 1.16

13.33b ± 0.84

0.001

T_CHOL (mmol/dL)

121.60a ± 1.34

121.67a ± 3.25

127.0ab ± 1.62

130.13b ± 1.54

0.01

HDL (mmol/dL)

87.43 ± 4.08

89.39 ± 4.61

96.75 ± 1.22

98.09 ± 2.91

0.08

Free Fatty Acids (μM)

156.99ab ± 4.59

177.36bc ± 7.73

146.2a ± 5.30

190.03c ± 5.36

<0.0001

Fasting Glucose (mg/dL)

     

  6-week

45.00a ± 2.10

52.03ab ± 3.41

62.50b ± 3.09

92.50c ± 3.87

<0.0001

  17-week

98.53ac ± 8.05

117.43ab ± 10.21

81.97c ± 6.53

132.90b ± 8.23

<0.001

Insulin (pg/ml)

525.5 ± 55.6

552.51 ± 56.57

539.73 ± 43.84

606.46 ± 54.50

0.75

HOMA-IR

3.65a ± 0.38

4.67ab ± 0.27

3.06a ± 0.31

5.86b ± 0.70

<0.001

C-Peptide (pg/ml)

1761.88a ± 200.3

1708.5a ± 123.17

1078.42b ± 86.51

1994.65a ± 150.65

<0.001

Amylin (pg/ml)

58.38 ± 5.39

58.82 ± 5.55

64.74 ± 4.24

59.75 ± 4.82

0.81

GIP (pg/ml)

129.13ab ± 17.9

95.46b ± 7.37

143.68c ± 11.91

113.75ac ± 8.69

0.04

Leptin (pg/ml)

5096.68a ± 662.7

9073.34b ± 1319.8

5460.9a ± 979.17

10917.55b ± 716.01

<0.001

MCP-1 (pg/ml)

69.06a ± 7.26

55.09a ± 6.03

69.05a ± 7.96

39.58b ± 4.53

0.01

Resistin (ng/ml)

25.24 ± 1.64

23.12 ± 1.33

21.64 ± 1.24

25.33 ± 1.67

0.26

TNF-α (pg/ml)

11.35a ± 1.35

7.77a ± 1.97

9.59a ± 1.40

30.56b ± 11.44

0.03

  1. HOMA-IR Homeostasis model of assessment of insulin resistance, GIP Gastric inhibitory polypeptide, MCP-1 Monocyte chemotactic peptide-1. Data are presented as Means ± SEM (n = 15 per diet group). Significant differences in Means are indicated using different letters abc for p-value of <0.05.