Prediabetic changes in gene expression induced by aspartame and monosodium glutamate in Trans fat-fed C57Bl/6 J mice

Collison, Kate S; Makhoul, Nadine J; Zaidi, Marya Z; Inglis, Angela; Andres, Bernard L; Ubungen, Rosario; Saleh, Soad; Al-Mohanna, Futwan A

doi:10.1186/1743-7075-10-44

Table 3 Diet-specific coordinated dysregulation of adipose tissue genes involved in glucose and lipid catabolism expressed as significant fold changes (P < 0.05, stringency ≥ ± 1.4-fold change in expression)

From: Prediabetic changes in gene expression induced by aspartame and monosodium glutamate in Trans fat-fed C57Bl/6 J mice

	Symbol	Induced by MSG	Induced by ASP	Induced by ASP + MSG	Sig.
Mitochondrial ß-oxidation genes
Peroxisome proliferator-activated recepto rγ, coactivator 1α	Ppargc1a	−1.94	−4.51	−3.49	0.048
Peroxisome proliferator-activated receptor α	Ppara	−1.01	−1.99	−2.03	0.052
Carnitine palmitoyltransferase 1B	Cpt1b	−1.99	−1.46	−1.63	0.028
Acyl-CoA dehydrogenase, short-chain	Acads	−1.36	−1.32	−1.57	0.024
Acyl-CoA dehydrogenase, very long chain	Acadvl	−1.32	−1.11	−1.67	0.036
Hydroxyacyl-CoA dehydrogenaseα	Hadha	−1.14	−1.31	−1.50	0.036
Hydroxyacyl-CoA dehydrogenase ß	Hadhb	−1.06	−1.43	−1.73	0.051
Citric acid cycle (TCA) genes
Aconitase 1, soluble	Aco1	−1.79	−1.69	−1.67	0.003
Isocitrate dehydrogenase 2 (NADP+), mitochondrial	Idh2	−1.19	−1.36	−1.44	0.022
Pyruvate dehydrogenase (lipoamide) α2	Pdha2	−1.43	−1.82	−2.36	0.004
Pyruvate dehydrogenase (lipoamide) ß	Pdhb	−1.30	−1.36	−1.62	0.043
Succinate dehydrogenase complex, subunit B	Sdhb	−1.32	−1.30	−1.44	0.001
Mitochondrial oxidative phosphorylation genes
NADH dehydrogenase (ubiquinone) 1 α subcomplex 5	Ndufa5	−1.14	−1.19	−1.47	0.007
NADH dehydrogenase (ubiquinone) 1 α subcomplex 12	Ndufa12	−1.21	−1.24	−1.46	0.004
NADH dehydrogenase (ubiquinone) 1ß subcomplex 2	Ndufb2	−1.12	−1.34	−1.55	0.016
NADH dehydrogenase (ubiquinone) 1ß subcomplex 6	Ndufb6	−1.11	−1.31	−1.46	0.050
NADH dehydrogenase (ubiquinone) 1ß subcomplex10	Ndufb10	1.01	−1.20	−1.76	0.010
NADH dehydrogenase (ubiquinone) Fe-S protein 1	Ndufs1	−1.62	−1.46	−2.16	0.006
NADH dehydrogenase (ubiquinone) Fe-S protein 6	Ndufs6	−1.29	−1.38	−1.53	0.037
NADH dehydrogenase (ubiquinone) flavoprotein 1	Ndufv1	−1.16	−1.27	−1.60	0.005
Succinate dehydrogenase complex, subunit B	Sdhb	−1.32	−1.30	−1.44	0.001
Ubiquinol-cytochrome c reductase, complex 3 subunit 6	Uqcr11	−1.44	−1.44	−1.58	0.006
COX assembly mitochondrial protein homolog	Cmc1	−1.17	−2.33	−2.53	0.040
Cytochrome c oxidase subunit 7a polypeptide 1	Cox7a1	−1.34	−1.25	−1.66	0.005
Cytochrome c oxidase, subunit 7b	Cox8b	−1.32	−1.13	−1.58	0.047
Cytochrome c oxidase assembly homolog	Cox11	−1.04	−1.32	−1.46	0.024
COX assembly mitochondrial protein homolog	Cmc1	−1.17	−2.33	−2.53	0.040
Uncoupling protein 2 (mitochondrial, proton carrier)	Ucp2	1.32	1.43	1.59	0.001
Glycolysis
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Pfkfb2	1.37	1.99	2.47	0.050
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	Pfkfb4	1.53	2.48	2.85	0.001
Mitochondrial biogenesis & assembly
Polymerase gamma (nuclear encoded)	Polg	1.42	1.72	1.94	0.038
Transcription factor A, mitochondrial	Tfam	−1.38	−1.32	−2.07	0.008
Mitochondrial fission process 1	Mtfp1	−1.37	−1.30	−1.64	0.004
Tu translation elongation factor, mitochondrial	Tufm	−1.07	2.14	1.68	0.011
G elongation factor, mitochondrial 2	Gfm2	−1.22	−2.30	−2.46	0.034
Mitochondrial ribosomal protein L3	Mrpl3	−1.06	2.03	1.79	0.054
Mitochondrial ribosomal protein L20	Mrpl20	−1.21	−1.41	−1.62	0.024
Mitochondrial ribosomal protein S24	Mrps24	1.53	−2.99	−3.31	0.037
Mitochondrial ribosomal protein S7	Mrps7	−1.12	−1.39	−1.63	0.032
Mitochondrial ribosomal protein S12	Mrps12	−1.36	−1.40	−1.73	0.011
Mitochondrial ribosomal protein S27	Mrps27	−1.16	−1.28	−1.55	0.050
Surfeit 1	Surf1	−1.22	−1.46	−1.57	0.026
Mitochondrial inner membrane organizing system 1	Minos1	−1.02	−1.44	−1.50	0.001
Inner membrane protein, mitochondrial	Immt	−1.13	−1.33	−1.66	0.009
Peroxiredoxin 5	Prdx5	−1.15	−1.51	−1.70	0.029
DnaJ (Hsp40) homolog, subfamily C, member 27	Dnajc27	−1.48	−1.80	−1.51	0.047
Diablo, IAP-binding mitochondrial protein	Diablo	1.14	1.51	1.63	0.007
Mitochondria-dependent apoptosis
BCL2-associated X protein	Bax	1.23	1.38	1.66	0.032
Tumor protein p53	Trp53	2.13	3.57	4.39	0.004
Caspase 9	Casp9	1.44	1.86	1.70	0.034
E2F transcription factor 1	E2f1	1.52	1.73	2.60	0.025
Peroxisomal genes
Peroxisomal biogenesis factor 1	Pex1	−1.14	−2.02	−2.05	0.054
Peroxisomal biogenesis factor 5	Pex5	−1.29	−1.55	−1.67	0.039
Peroxisomal biogenesis factor 7	Pex7	−1.10	−1.74	−1.46	0.026
Peroxisomal biogenesis factor 11 α	Pex11a	−1.11	−1.40	−1.48	0.012
Peroxisomal biogenesis factor 13	Pex13	−1.17	−1.60	−1.43	0.055
Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	Ehhadh	−1.40	−1.06	−1.55	0.029
Acetyl-CoA acyltransferase 1	Acaa1a	−1.32	−1.35	−1.59	0.056
ATP-binding cassette, sub-family D (ALD), member 1	Abcd1	1.29	1.69	2.09	0.051
Epoxide hydrolase 2	Ephx2	−1.17	−1.62	−1.66	0.010
Calcium homeostasis genes
Calcium homeostasis endoplasmic reticulum protein	Cherp	1.55	2.21	2.37	0.002
Calcium homeostasis modulator 2	Calhm2	1.19	1.61	2.09	0.001
Calcium activated nucleotidase 1	Cant1	1.16	1.45	1.86	0.002
Mitochondrial calcium uniporter	Ccdc109a	1.11	1.44	1.70	0.047
Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Cacna1a	1.37	1.65	1.62	0.016
S100 calcium binding protein A8	S100a8	−1.15	−1.60	−1.57	0.033
Mitochondrial calcium uptake 1	Cbara1	−1.08	−1.80	−1.71	0.038
Calcium channel, voltage-dependent, gamma subunit 4	Cacng4	−1.26	−1.63	−1.85	0.000
Calcium binding protein 2	Cabp2	−1.26	−1.71	−1.98	0.015
S100 calcium binding protein A13	S100a13	−1.19	−2.09	−1.99	0.039
Solute carrier family 8 (sodium/calcium exchanger), member 1	Slc8a1	−1.40	−2.28	−2.01	0.042
Calcium channel, voltage-dependent, gamma subunit 8	Cacng8	−1.21	−1.87	−2.13	0.026
Calcium channel, voltage-dependent, T type, alpha 1I subunit	Cacna1i	−1.21	−1.38	−2.61	0.045
Calcium channel, voltage-dependent, beta 2 subunit	Cacnb2	−1.56	−3.66	−2.76	0.037
Calcium channel, voltage-dependent, alpha 2/delta subunit 4	Cacna2d4	−1.77	−3.32	−3.35	0.019
Calreticulin 3	Calr3	−1.19	−1.83	−1.71	0.035

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