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Table 6 Relative mRNA levels of genes involved in angiogenesis, mitochondrial respiratory chain and uncoupling proteins in M. rectus femoris of lean rats (lean control), obese Zucker rats fed a control diet (obese control) or obese Zucker rats fed a diet supplemented with 3 g/kg diet carnitine (obese carnitine) for 4 wk 1

From: Carnitine supplementation to obese Zucker rats prevents obesity-induced type I to type II muscle fiber transition and favors an oxidative phenotype of skeletal muscle

  Lean Obese Obese
control control carnitine
  Fold of obese control
Angiogenesis
VEGFA 0.81 ± 0.18 1.00 ± 0.30 1.30 ± 0.37
VEGFB 1.62 ± 0.35ab 1.00 ± 0.19b 2.21 ± 0.28a
TCA cycle and respiratory chain
SDHA 1.26 ± 0,25ab 1.00 ± 0.24b 2.18 ± 0.40a
Thermogenesis
UCP1 1.67 ± 0.35b 1.00 ± 0.12b 7.06 ± 1.27a
UCP2 1.07 ± 0.23b 1.00 ± 0.24b 3.39 ± 0.34a
UCP3 0.97 ± 0.20 1.00 ± 0.25 1.92 ± 0.70
  1. 1Data are expressed as means ± SEM, n = 12 rats/group. Means and SEM of the other groups were presented as fold of the obese control group, which mean was set to 1. Means in a row without a common letter differ (P < 0.05).