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Table 6 Estimates of D9D activity according to genotype for each SCD1 SNP in Asians

From: Plasma concentration of cis 9trans 11 CLA in males and females is influenced by SCD1 genetic variations and hormonal contraceptives: a cross-sectional study

 

[18:2c9t11/18:1 t11] in males

[18:2c9t11/18:1 t11] in females

MM

Mm

mm

P-value

MM

Mm

mm

P-value

rs10883463

1.039 ± 0.041

0.813 ± 0.064

-

0.46

1.085 ± 0.027

0.783

-

0.23

rs17669878

1.094 ± 0.059

0.966 ± 0.052

0.910 ± 0.118

0.18

1.035 ± 0.035

1.139 ± 0.043

1.061 ± 0.096

0.28

rs2060792

0.949 ± 0.049

1.052 ± 0.064

1.185 ± 0.107

0.27

1.090 ± 0.040

1.058 ± 0.038

1.185 ± 0.084

0.37

rs3071

1.069 ± 0.061

0.959 ± 0.048

1.103 ± 0.121

0.34

1.052 ± 0.038

1.143 ± 0.041

0.939 ± 0.063

0.11

rs3793766

1.035 ± 0.047

1.053 ± 0.081

0.752 ± 0.036

0.88

1.072 ± 0.030

1.117 ± 0.056

0.906 ± 0.081

0.59

rs3793767

0.993 ± 0.057

1.028 ± 0.058

1.120 ± 0.104

0.66

1.109 ± 0.044

1.051 ± 0.037

1.120 ± 0.067

0.54

rs490726

1.035 ± 0.048

1.070 ± 0.077

0.795 ± 0.051

0.68

1.056 ± 0.034

1.128 ± 0.044

1.038 ± 0.101

0.19

rs522951

0.975 ± 0.053

1.030 ± 0.062

1.164 ± 0.102

0.40

1.095 ± 0.041

1.058 ± 0.038

1.156 ± 0.080

0.42

rs569184

1.041 ± 0.049

1.052 ± 0.076

0.807 ± 0.064

0.86

1.045 ± 0.034

1.129 ± 0.046

1.070 ± 0.093

0.25

rs575338

N/A

   

1.082 ± 0.027

0.815 ± 0.143

-

0.47

  1. Results of analysis of 10 SNPs from SCD1 for associations with D9D activity index [182c9t11:181 t11]. P-values were determined using linear regression models which were adjusted for BMI, age, % of Total Energy from Dietary Fat and physical activity. Caucasian Males: n = 113; Caucasian females: n = 298; Asian Males: n = 98; Asian Females: n = 277. Abbreviations: D9D, delat-9-desaturase; M, major; m, minor; na, not applicable; ‘-’ indicates that no subjects with this genotype were present in this population.
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Nutrition & Metabolism

ISSN: 1743-7075

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