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Figure 5 | Nutrition & Metabolism

Figure 5

From: Grape seed proanthocyanidins ameliorate pancreatic beta-cell dysfunction and death in low-dose streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats partially by regulating endoplasmic reticulum stress

Figure 5

Effect of GSPs on islet cell apoptosis in normal and diabetic rats. The slides were visualized by fluorescence microscope. The insulin antibody and fluorescein isothiocyanate (FITC)-labeled secondary antibody were used to probe insulin (green). 4’, 6-diamidino-2-phenylindole (DAPI) was used to visualize nuclei (blue). Apoptotic cells exhibited strong nuclear red fluorescence using regional terminal deoxynucleotidyl transferase-mediated dUTP biotin nick end labeling (TUNEL) staining. See Figure 2 for groups and treatment. Scale bar = 50 μm.

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