Skip to main content

Advertisement

Table 1 Body weight (BW), food intake, homoeostasis model assessment of beta-cell function (HOMA-B), pancreas/BW ratio and the frequency of apoptotic islet cells in normal and diabetic rats after 16 weeks of GSPs treatment

From: Grape seed proanthocyanidins ameliorate pancreatic beta-cell dysfunction and death in low-dose streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats partially by regulating endoplasmic reticulum stress

Parameter Normal rats Diabetic rats
Vehicle GSPs (mg/kg BW) Vehicle GSPs (mg/kg BW)
  250   125 250 500
Initial BW (g) 459.85 ± 6.93 466.73 ± 7.17 441. 06 ± 11.05 453.72 ± 13.99 437.92 ± 9.71 454.30 ± 10.34
Final BW (g) 584.29 ± 13.44 # 544.63 ± 14.88 # 417.88 ± 9.75 * 436.38 ± 9.00 * 447.57 ± 12.74 * 446.63 ± 10.57 *
Initial food intake (g/day) 19.43 ± 0.83 # 17.77 ± 1.32 # 30.30 ± 1.03 * 29.93 ± 1.09 * 29.15 ± 1.69 * 29.81 ± 0.44 *
Final food intake (g/day) 23.88 ± 1.87 # 20.31 ± 0.73 # 38.83 ± 1.64 * 37.31 ± 1.65 * 34.30 ± 1.46 * 30.74 ± 0.23 *
HOMA-B 176.34 ± 7.88 # 228.63 ± 10.63 * # 35.61 ± 1.62 * 47.77 ± 3.06 * 46.76 ± 1.54 * 51.51 ± 2.91 * #
Pancreas weight (g) 1.33 ± 0.03 # 1.31 ± 0.04 # 1.16 ± 0.04 * 1.19 ± 0.07 * 1.20 ± 0.04 1.22 ± 0.04
Pancreas/BW ratio (‰) 2.27 ± 0.09 # 2.40 ± 0.10 # 2.84 ± 0.15 * 2.73 ± 0.10 * 2.69 ± 0.11 * 2.74 ± 0.09 *
Apoptotic cells/islet 1.75 ± 0.37 # 1.58 ± 0.31 # 8.92 ± 0.87 * 7.75 ± 0.77 * 7.42 ± 0.79 * 5.36 ± 0.54 * #
  1. BW and food intake were measured once a week after induction of diabetes. The frequency of apoptotic islet cells was evaluated by averaging the number of TUNEL-positive cells in approximately 50 islets from each group. The other data were means ± SEM of 10 rats of each group.
  2. * Designated statistically significant difference from vehicle-treated normal rats, P < 0.05, # designated statistically significant difference from vehicle-treated diabetic rats, P < 0.05.