Lower serum levels of total cholesterol are associated with higher urinary levels of 8-hydroxydeoxyguanosine

Nutrition & Metabolism

Table 2 Regression coefficients in multiple linear regression analyses between serum cholesterols and urinary 8-OHdG

	n	Total cholesterol			HDL-cholesterol			LDL-cholesterol
	n	β	S.E.	p	β	S.E.	p	β	S.E.	p
Total subjects	503	−0.0015	0.0006	0.01	−0.0010	0.0013	0.46	−0.0012	0.0007	0.07
Men	294	−0.0015	0.0006	0.02	−0.0014	0.0016	0.39	−0.0009	0.0007	0.18
Smoker	134	−0.0017	0.0008	0.04	−0.0029	0.0023	0.22	−0.0007	0.0008	0.37
Non-Smoker	160	−0.0015	0.0010	0.15	−0.0008	0.0021	0.70	−0.0012	0.0012	0.31
Women	209	−0.0022	0.0012	0.08	−0.0004	0.0025	0.86	−0.0030	0.0015	0.04
Age < 48	146	−0.0040	0.0015	0.01	−0.0052	0.0029	0.08	−0.0041	0.0019	0.04
Age ≥ 48	63	−0.0014	0.0019	0.47	0.0033	0.0044	0.46	−0.0027	0.0021	0.22

8-OHdG 8-hydroxydeoxyguanosine, S.E standard error, HDL high-density lipoprotein, LDL low-density lipoprotein.
All analyses were adjusted for sex, age, body mass index and smoking status.
LDL-cholesterol was estimated by applying the Friedewald’s formula (LDL cholesterol = total cholesterol - HDL cholesterol - trigriceride/5) only among subjects with fasting blood samples (n = 481).

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