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Figure 1 | Nutrition & Metabolism

Figure 1

From: Zerumbone, a tropical ginger sesquiterpene, ameliorates streptozotocin-induced diabetic nephropathy in rats by reducing the hyperglycemia-induced inflammatory response

Figure 1

Effects of treatments on kidney histopathology. (A) Representative photomicrographs (original magnification, 400×) of PAS-stained kidney sections from STZ-diabetic rats treated for eight weeks with zerumbone (ZER) or rosiglitazone (RGZ). STZ-diabetic rats were dosed by oral gavage once daily for eight weeks with 20 mg/kg ZER (STZ + ZER 20), 40 mg/kg ZER (STZ + ZER 40) or 5 mg/kg RGZ (STZ + RGZ). Normal (normal + VEH) or STZ-diabetic rats receiving vehicle treatment (STZ + VEH) were administered the same volume of vehicle (VEH) used to dissolve test medications. (B) Results of quantification of the mesangial expansion index for each group. Values (mean ± SD) were obtained for each group of 4 animals. bp < 0.01 compared to vehicle-treated normal rats. cp < 0.05 and dp < 0.01 compared to vehicle-treated STZ-diabetic rats, respectively.

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Nutrition & Metabolism

ISSN: 1743-7075

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