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Figure 2 | Nutrition & Metabolism

Figure 2

From: Zerumbone, a tropical ginger sesquiterpene, ameliorates streptozotocin-induced diabetic nephropathy in rats by reducing the hyperglycemia-induced inflammatory response

Figure 2

Effects of treatments on renal macrophage infiltration. (A) Immunohistochemical staining for macrophage (ED-1-positive) cells in the renal tissues of STZ-diabetic rats treated for eight weeks with zerumbone (ZER) or rosiglitazone (RGZ). STZ-diabetic rats were dosed by oral gavage once daily for eight weeks with 20 mg/kg ZER (STZ + ZER 20), 40 mg/kg ZER (STZ + ZER 40) or 5 mg/kg RGZ (STZ + RGZ). Normal (normal + VEH) or STZ-diabetic rats receiving vehicle treatment (STZ + VEH) were given the same volume of vehicle (VEH) used to dissolve test medications. (B) Quantified results are shown for number of macrophages (ED-1-positive cells). Values (mean ± SD) were obtained for each group of 4 animals. bp < 0.01 compared to vehicle-treated normal rats. cp < 0.05 and dp < 0.01 compared to vehicle-treated STZ-diabetic rats, respectively.

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