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Figure 4 | Nutrition & Metabolism

Figure 4

From: Zerumbone, a tropical ginger sesquiterpene, ameliorates streptozotocin-induced diabetic nephropathy in rats by reducing the hyperglycemia-induced inflammatory response

Figure 4

Effects of treatments on renal TGF-β1 and fibronectin protein expression. (A) Representative immunoblots of protein expression of TGF-β1 and fibronectin in renal tissues of STZ-diabetic rats treated for eight weeks with zerumbone (ZER) or rosiglitazone (RGZ). STZ-diabetic rats were dosed by oral gavage once daily for eight weeks with 20 mg/kg ZER (ZER 20), 40 mg/kg ZER (ZER 40) or 5 mg/kg RGZ (RGZ). Normal (normal + VEH) or STZ-diabetic rats receiving vehicle treatment (STZ + VEH) were administered the same volume of vehicle (VEH) used to dissolve test medications. (B) Ratios of TGF-β1/β-actin and fibronectin/β-actin are expressed as the mean with SD (n = 4 per group) in each column. ap < 0.01 and bp < 0.01 compared to vehicle-treated normal rats. cp < 0.05 and dp < 0.01 compared to vehicle-treated STZ-diabetic rats, respectively.

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Nutrition & Metabolism

ISSN: 1743-7075

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