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Table 5 Effect of HCD in P2Y 13 -/- mice on intestinal mRNA expression of genes involved in lipid homeostasis

From: Lack of P2Y13 in mice fed a high cholesterol diet results in decreased hepatic cholesterol content, biliary lipid secretion and reverse cholesterol transport

Gene

 

Fold-change

Accession N°

Gene title

Npc1l1

1.00 ± 0.21

1.39 ± 0.21 (p = 0.36)

NM_207242

Niemann-Pick C1-like protein 1

Abcg5

1.00 ± 0.26

1.53 ± 0.24 (p = 0.36)

NM_026180

ATP-binding cassette, sub-family G, member 5

Abcg8

1.00 ± 0.21

1.47 ± 0.19 (p = 0.18)

NM_026180

ATP-binding cassette, sub-family G, member 8

AbcA1

1.00 ± 0.15

1.52 ± 0.23 (p = 0.18)

NM_013454

ATP-binding cassette, sub-family A, member 1

Abcg1

1.00 ± 0.22

0.89 ± 0.11 (p = 0.94)

NM_009593

ATP-binding cassette, sub-family G, member 1

Scarb1

1.00 ± 0.25

1.41 ± 0.32 (p = 0.73)

NM_016741

Scavenger receptor class B, member 1

Oatp/Slco1a1

1.00 ± 0.41

0.81 ± 0.17 (p = 0.94)

NM_013797

Solute carrier organic anion transporter family, member 1A2

Fgf15

1.00 ± 0.28

1.09 ± 0.27 (p = 0.94)

NM_008003

Fibroblast growth factor 15

  1. Real-time PCR was performed on individual intestine of 3 h fasted mice (n = 6 mice per group). For all genes, the fold change was calculated by dividing the P2Y13.-/- mice value by the wild-type mice value (e.g. an increase of 80% from wild-type is reported as 1.80).