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Table 5 Effect of HCD in P2Y 13 -/- mice on intestinal mRNA expression of genes involved in lipid homeostasis

From: Lack of P2Y13 in mice fed a high cholesterol diet results in decreased hepatic cholesterol content, biliary lipid secretion and reverse cholesterol transport

Gene   Fold-change Accession N° Gene title
Npc1l1 1.00 ± 0.21 1.39 ± 0.21 (p = 0.36) NM_207242 Niemann-Pick C1-like protein 1
Abcg5 1.00 ± 0.26 1.53 ± 0.24 (p = 0.36) NM_026180 ATP-binding cassette, sub-family G, member 5
Abcg8 1.00 ± 0.21 1.47 ± 0.19 (p = 0.18) NM_026180 ATP-binding cassette, sub-family G, member 8
AbcA1 1.00 ± 0.15 1.52 ± 0.23 (p = 0.18) NM_013454 ATP-binding cassette, sub-family A, member 1
Abcg1 1.00 ± 0.22 0.89 ± 0.11 (p = 0.94) NM_009593 ATP-binding cassette, sub-family G, member 1
Scarb1 1.00 ± 0.25 1.41 ± 0.32 (p = 0.73) NM_016741 Scavenger receptor class B, member 1
Oatp/Slco1a1 1.00 ± 0.41 0.81 ± 0.17 (p = 0.94) NM_013797 Solute carrier organic anion transporter family, member 1A2
Fgf15 1.00 ± 0.28 1.09 ± 0.27 (p = 0.94) NM_008003 Fibroblast growth factor 15
  1. Real-time PCR was performed on individual intestine of 3 h fasted mice (n = 6 mice per group). For all genes, the fold change was calculated by dividing the P2Y13.-/- mice value by the wild-type mice value (e.g. an increase of 80% from wild-type is reported as 1.80).