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Table 2 The effect of melatonin administration on morphological changes as assessed by histological analysis of kidneys in rats ( n = 10)

From: Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway

  Groups
Changes Control Melatonin Cisplatine Melatonin + Cisplatine
Vaculation - - ++ +
Interstitial edema - - + -
Tubular brush border loss - - + +/−
Tubular necrosis - - ++ +
Tubular atrophy - - + +/−
Interstitial inflammation - - +++ +/−
  1. −, none; +, mild damage; ++, moderate damage; and +++, severe damage are semiquantitative scores given by a pathologist unaware of the type of treatment according to method of Ross et al. (1989).