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Table 2 The effect of melatonin administration on morphological changes as assessed by histological analysis of kidneys in rats ( n = 10)

From: Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway

 

Groups

Changes

Control

Melatonin

Cisplatine

Melatonin + Cisplatine

Vaculation

-

-

++

+

Interstitial edema

-

-

+

-

Tubular brush border loss

-

-

+

+/−

Tubular necrosis

-

-

++

+

Tubular atrophy

-

-

+

+/−

Interstitial inflammation

-

-

+++

+/−

  1. −, none; +, mild damage; ++, moderate damage; and +++, severe damage are semiquantitative scores given by a pathologist unaware of the type of treatment according to method of Ross et al. (1989).
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Nutrition & Metabolism

ISSN: 1743-7075

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