Skip to main content

Table 1 Metabolic parameters at 8-weeks-old mice

From: Miglitol increases energy expenditure by upregulating uncoupling protein 1 of brown adipose tissue and reduces obesity in dietary-induced obese mice

 

n

NC

NCM

HF

HFM

Body weight (g)

10-11

21.5 ± 0.2

22.2 ± 0.2

27.3 ± 0.4 a, b

25.8 ± 0.4 a, b, c

Glucose (mg/dl)

5

118 ± 6.6

129 ± 15.4

282 ± 4.1 a, b

240 ± 9.1 a, b, c

Total cholesterol (mg/dl)

5-7

62 ± 4.7

68 ± 4.9

150 ± 7.2 a, b

141 ± 4.2 a, b

Triglyceride (mg/dl)

6

42 ± 8.4

45 ± 5.7

42 ± 4.9

46 ± 5.2

Insulin (μU/ml)

5

5.3 ± 1.2

3.4 ± 0.5

12.3 ± 1.9 a, b

6.7 ± 1.2

HOMA-R

5

1.4 ± 0.3

1.1 ± 0.3

8.4 ± 1.3 a, b

4.0 ± 0.7 a, b, c

Weight of epididymal white adipose tissue (g)

9-14

0.27 ± 0.02

0.28 ± 0.01

1.1 ± 0.08 a, b

0.85 ± 0.04 a, b, c

Weight of subcutaneous white adipose tissue (g)

6

0.3 ± 0.03

Not measured

1.5 ± 0.15 a

0.98 ± 0.12 a, c

Active glucagon-like peptide1 (pg/ml)

8-9

54.8 ± 7.9

61.1 ± 4.9

66 ± 7.5

76.9 ± 14.4

Concentration of miglitol (μmol/L)

3-4

Not measured

0.06 ± 0.02

Not measured

0.26 ± 0.13

  1. Values are means ± SE for 3–14 mice. Blood samples were collected under fasting conditions. aP < 0.05, vs mice fed normal chow diet (NC). bP < 0.05, vs mice fed normal chow diet plus miglitol (NCM). cP < 0.05, vs mice fed high-fat diet alone (HF).