Skip to main content

Table 1 Metabolic parameters at 8-weeks-old mice

From: Miglitol increases energy expenditure by upregulating uncoupling protein 1 of brown adipose tissue and reduces obesity in dietary-induced obese mice

  n NC NCM HF HFM
Body weight (g) 10-11 21.5 ± 0.2 22.2 ± 0.2 27.3 ± 0.4 a, b 25.8 ± 0.4 a, b, c
Glucose (mg/dl) 5 118 ± 6.6 129 ± 15.4 282 ± 4.1 a, b 240 ± 9.1 a, b, c
Total cholesterol (mg/dl) 5-7 62 ± 4.7 68 ± 4.9 150 ± 7.2 a, b 141 ± 4.2 a, b
Triglyceride (mg/dl) 6 42 ± 8.4 45 ± 5.7 42 ± 4.9 46 ± 5.2
Insulin (μU/ml) 5 5.3 ± 1.2 3.4 ± 0.5 12.3 ± 1.9 a, b 6.7 ± 1.2
HOMA-R 5 1.4 ± 0.3 1.1 ± 0.3 8.4 ± 1.3 a, b 4.0 ± 0.7 a, b, c
Weight of epididymal white adipose tissue (g) 9-14 0.27 ± 0.02 0.28 ± 0.01 1.1 ± 0.08 a, b 0.85 ± 0.04 a, b, c
Weight of subcutaneous white adipose tissue (g) 6 0.3 ± 0.03 Not measured 1.5 ± 0.15 a 0.98 ± 0.12 a, c
Active glucagon-like peptide1 (pg/ml) 8-9 54.8 ± 7.9 61.1 ± 4.9 66 ± 7.5 76.9 ± 14.4
Concentration of miglitol (μmol/L) 3-4 Not measured 0.06 ± 0.02 Not measured 0.26 ± 0.13
  1. Values are means ± SE for 3–14 mice. Blood samples were collected under fasting conditions. aP < 0.05, vs mice fed normal chow diet (NC). bP < 0.05, vs mice fed normal chow diet plus miglitol (NCM). cP < 0.05, vs mice fed high-fat diet alone (HF).