Nutrition & Metabolism

Table 1 Concentrations of selected plasma oxylipins and relative tissue mRNA abundances for oxylipin-relevant targets in mice with developing obesity

From: A diet containing a nonfat dry milk matrix significantly alters systemic oxylipins and the endocannabinoid 2-arachidonoylglycerol (2-AG) in diet-induced obese mice

	Cohort 1
	Control		HighCa		NFDM
Oxylipins (nM)	Mean	SEM	Mean	SEM	Mean	SEM
∑C18 Diols
15,16-DiHODE	1.68	0.1666^a	1.442	0.1114^a	0.4278	0.04809^b
9,10-DiHOME	4.232	0.08353^a	4.192	0.1493^a	3.489	0.08201^b
12,13-DiHOME	2.525	0.08735^a	2.365	0.1339^a,b	2.14	0.08462^b
9,10-DiHODE	0.8443	0.01388^a	0.865	0.02576^a	0.7562	0.01735^b
∑C20 Diols
8,9-DiHETrE	3.995	0.1728^a	3.345	0.1401^b	1.536	0.07598^c
5,6-DiHETrE	3.634	0.1948^a	3.112	0.1064^b	0.9325	0.06361^c
11,12-DiHETrE	0.7705	0.05849^a	0.7053	0.03648^a,b	0.5728	0.03826^b
∑Epoxides
15(16)-EpODE	2.001	0.128^a	1.899	0.1152^a	1.419	0.0811^b
12,13-EpOME	3.038	0.1481^a,b	2.8	0.08468^a	3.345	0.07784^b
∑Alcohols
5-HEPE	0.7138	0.02803^a	0.7739	0.02809^a,b	0.8253	0.02512^b
mRNA abundance (%)
*Adipose*
Cyp2j6	100	6.8^a	76.2	4.8^b	82.6	5.1^a,b
Ephx2	100	13.7^a	70.4	7.9^a,b	62.0	5.3^b
Leptin	100	7.2^a	90.3	7.5^a,b	68.9	5.8^b
Trpv1	100	8.4^a	73.1	5.8^b	67.5	3.2^b
*Liver*
Ephx2	100.0	8.8^a	105.8	5.5^a	162.8	21.5^b

SEM - Standard Error of the Mean.
n = 10/diet treatment group.
For mRNA abundance, expression values are calculated relative to control; transcript level for CONTROL mice was considered 100%.
Data were tested for normality using D’Agostino and Pearson’s omnibus test.
To test for diet treatment differences, normal data were assessed by one-way ANOVA with Tukey post-hoc test, non-normal data were assessed by Kruskal-Wallis.
Values with different superscript letter are significantly different (P < 0.05). ns - not significant.

Back to article page

ISSN: 1743-7075

Contact us

General enquiries: journalsubmissions@springernature.com