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Table 2 Concentrations of selected plasma monoacylglycerols (MAG), N-acylamides (NAE), and relative tissue mRNA abundances for endocannabinoid-relevant targets in mice with developing obesity

From: A diet containing a nonfat dry milk matrix significantly alters systemic oxylipins and the endocannabinoid 2-arachidonoylglycerol (2-AG) in diet-induced obese mice

 

Cohort 1

 

Control

HighCa

NFDM

Lipid analyte (nM)

Mean

SEM

Mean

SEM

Mean

SEM

∑MAG

1-AG

2.758

0.1366a

3.096

0.1573a,b

3.599

0.1214b

2-AG

5.718

0.3126a

5.553

0.3529a

8.841

0.3825b

1-LG

7.147

0.1388a

7.606

0.1195a

8.369

0.228b

2-LG

7.929

0.1191a

8.235

0.09149a

9.005

0.1418b

1-OG

7.626

0.09071a

8.196

0.1491a,b

8.287

0.2314b

2-OG

25. 51

2.242a

33. 74

2.376a,b

37. 31

4.725b

∑NAE

DGLEA

0.4023

0.04208a,b

0.437

0.04364a

0.2798

0.02968b

LEA

22. 84

12. 06a

7.488

3.736a

2.368

1.181b

mRNA abundance (%)

Adipose

Cnr1

100

9.8a

91. 3

10. 8a,b

63. 8

3.7b

Cnr2

100

13. 9a

130.3

13. 0a

54. 3

10. 7b

Mgll

100

10. 4a

71. 1

5.8b

78. 2

5.3a,b

Liver

Pnpla2

100

8.4a

254.9

49. 8b

234.2

42. 7a,b

  1. SEM - Standard Error of the Mean.
  2. n = 10/diet treatment group.
  3. For mRNA abundance, expression values are calculated relative to control; transcript level for CONTROL mice was considered 100%.
  4. Data were tested for normality using D’Agostino and Pearson’s omnibus test.
  5. To test for diet treatment differences, normal data were assessed by one-way ANOVA with Tukey post-hoc test, non-normal data were assessed by Kruskal-Wallis.
  6. Values with different superscript letter are significantly different (P < 0.05). ns - not significant.