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Table 4 Concentrations of selected plasma monoacylglycerols (MAG), N-acylamides (NAE), and relative tissue mRNA abundances for endocannabinoid-relevant targets in mice with pre-existing obesity

From: A diet containing a nonfat dry milk matrix significantly alters systemic oxylipins and the endocannabinoid 2-arachidonoylglycerol (2-AG) in diet-induced obese mice

 

Cohort 2

 

Control

HighCa

NFDM

Lipid analyte (nM)

Mean

SEM

Mean

SEM

Mean

SEM

∑MAG

1-AG

2.922

0.1194ns

3.132

0.2386ns

3.437

0.2354ns

2-AG

5.44

0.07841a

5.437

0.06266a

5.919

0.1294b

1-LG

4.964

0.222a

5.295

0.1451a,b

6.067

0.291b

2-LG

8.196

0.1433a

8.293

0.09063a

9.149

0.1696b

1-OG

7.399

0.1517ns

7.829

0.1807ns

7.828

0.2093ns

2-OG

8.197

0.1308ns

8.553

0.1325ns

8.665

0.1947ns

∑NAE

AEA

2.093

0.1251ns

2.81

0.2002ns

1.744

0.1747ns

LEA

20. 92

1.406ns

22. 21

1.996ns

16. 22

1.885ns

mRNA abundance (%)

Adipose

Mgll

100

12. 0a

73. 5

10. 9a

162.9

19. 3b

Cnr1

100

15. 4ns

91. 2

13. 7ns

130.2

20. 6ns

Cnr2

100

15. 9ns

140.8

18. 7ns

85. 08

14. 1ns

Pnpla2

100

13. 5a,b

68. 7

8.8a

132.9

17. 7b

Nodose

Cnr1

100

10. 2a,b

88. 7

6.5a

117.6

7.1b

  1. SEM - Standard Error of the Mean.
  2. n = 10/diet treatment group.
  3. For mRNA abundance, expression values are calculated relative to control; transcript level for CONTROL mice was considered 100%.
  4. Data were tested for normality using D’Agostino and Pearson’s omnibus test.
  5. To test for diet treatment differences, normal data were assessed by one-way ANOVA with Tukey post-hoc test, non-normal data were assessed by Kruskal-Wallis.
  6. Values with different superscript letter are significantly different (P < 0.05). ns - not significant.