Figure 1

Sudachitin inhibits weight gain in high-fat diet-fed mice. Mice were fed a low-fat control diet or a high-fat diet and were treated with 5 mg/kg sudachitin or vehicle for 12 weeks (n = 10 per group). Mice were fasted for 16 h at the end of the study. Body weight was measured weekly (A) and food intake was measured every 2 days (B) for 12 weeks. Values are mean ± standard error of the mean (A) or mean ± standard deviation (B). *P < 0.05 sudachitin administration vs. control treatment, # P < 0.05 high-fat diet-fed vs. control diet-fed animals. Cont + Veh: vehicle-treated, control diet group (closed squares in panel A); Cont + Sud: sudachitin-treated, control diet group (open squares); HFD + Veh: vehicle-treated, high-fat diet group (closed circles); HFD + Sud: sudachitin-treated, high-fat diet group (open circles).