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Figure 3 | Nutrition & Metabolism

Figure 3

From: Embryonic viability, lipase deficiency, hypertriglyceridemia and neonatal lethality in a novel LMF1-deficient mouse model

Figure 3

Characterization of LMF1-/- mice. (A) Survival of LMF1-deficient (LMF1-/-) progeny during days 1 to 4 (d1 to d4) after birth. Dashed line indicates Mendelian frequency (25%) of -/- genotype as expected from heterozygous matings. White numbers show total number of pups genotyped at each time-point. Asterisks indicate significant (p < 0.05) differences from expected genotype frequencies (χ2 test). (B) White fat-cake indicates hyperlipidemia in plasma of -/- neonates. (C) Plasma triglyceride (TG), (D) total cholesterol (TC), and (E) HDL-cholesterol (HDL-C) levels are shown in newborn mice. (F) Plasma triglyceride and (G) cholesterol profiles were determined by FPLC analysis. (H) Post-heparin LPL and (I) HL activities in newborn mice. *, p < 0.05.

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