Figure 7From: Homocysteine downregulates gene expression of heme oxygenase-1 in hepatocytesSchematic model of effect of Hcy on HO-1 expression via regulation of Bach1 and Nrf2. With high levels of Hcy, expression of Bach1, a repressor of HO-1 gene expression, is increased. Bach1 also competes with Nrf2 to bind antioxidant response element (ARE), then reduces HO-1 transcription.Back to article page