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Figure 3 | Nutrition & Metabolism

Figure 3

From: Racial differences between African-American and white women in insulin resistance and visceral adiposity are associated with differences in apoCIII containing apoAI and apoB lipoproteins

Figure 3

Metabolic pathways suggested by the results of this study. Increased visceral adipose tissue increases flux of FFA to the liver. The liver responds by increasing the secretion of apoC-III in apoB lipoproteins. Lower total body insulin sensitivity including in skeletal muscle and peripheral adipose tissue increases plasma FFA, which increases secretion of apoC-III in apoB lipoproteins. Lower insulin sensitivity reduces apoAI level in HDL with apoCIII, and in HDL without apoCIII. African-American race is associated with increased apoAI of HDL with apoCIII, and decreased apoCIII in apoB lipoproteins, independent of differences in insulin sensitivity and VAT.

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Nutrition & Metabolism

ISSN: 1743-7075

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