Metabolic pathways suggested by the results of this study. Increased visceral adipose tissue increases flux of FFA to the liver. The liver responds by increasing the secretion of apoC-III in apoB lipoproteins. Lower total body insulin sensitivity including in skeletal muscle and peripheral adipose tissue increases plasma FFA, which increases secretion of apoC-III in apoB lipoproteins. Lower insulin sensitivity reduces apoAI level in HDL with apoCIII, and in HDL without apoCIII. African-American race is associated with increased apoAI of HDL with apoCIII, and decreased apoCIII in apoB lipoproteins, independent of differences in insulin sensitivity and VAT.