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Table 2 Fold differences in abundance of hepatic proteins identified by LC-MS/MS in C57BL/6 mice fed a diet high or low in n-3 polyunsaturated fatty acids

From: Novel regulatory roles of omega-3 fatty acids in metabolic pathways: a proteomics approach

#Protein Function High n-3 PUFA Low n-3 PUFA GI Mass Score Matches
Ornithine aminotransferase Nitrogen homeostasis 28.25↑   8393866 48723 60 2 (1)
S-adenosylmethionine synthase One-carbon metabolism 1.88↑   19526790 44051 503 11 (8)
Disulfide isomerase-A3 Protein folding 9.18↑   351707448 57366 81 2 (1)
Aldehyde dehydrogenase Energy production   1.43↑ 560645 56686 55 1 (1)
Adenosine kinase Phosphorylation   1.66↑ 19527306 40466 379 12 (2)
Lactoylglutathione lyase Detoxification 1.69↑   165932331 20967 278 7 (6)
  1. The images of the total protein pattern of 2D-gels were captured by video imaging using the ImageScanner III (LabScan 6.0 software, GE Healthcare, Life Sciences, Sweden). Progenesis Samespots, version 3.1, a specialized software (Non-linear Dynamics, Newcastle upon Tyne, UK) was then used to align and quantify the protein spots from the captured 2D-gel images. PUFA, polyunsaturated fatty acids; GI, GenBank sequence identification number; ↑= upregulation.