Effects of dietary naringenin on caloric intake, body weight, and metabolic measurements. OVX C57BL/6 J mice were fed the control diet for 11 weeks then randomized to continuation of the control diet (n = 9) or switched to 3% wt/wt naringenin supplementation of the control diet (n = 10) for the weeks 12–22. Average daily caloric intake (A) of two groups (n = 2/group) and weekly body weight (B) of the CON (n = 9) and NAR (n = 10) group were determined. At week 17, CLAMS chambers were used to measure locomotor activity (ambulation) in the horizontal plane by infrared beam breaks (C) and estimated energy expenditure (heat) after controlling for body weight (D) in the dark and light phase for 24-h following a 24-h acclimation (n = 6/group). Fasting glucose levels (E) were measured at week 5 and week 18, (CON, n = 9; NAR, n = 10). Fasting insulin levels (F) were determined after 22 weeks of experimental period (n = 6/group). HOMA-IR values (G) were derived from fasting plasma glucose and insulin (n = 4/group). Values are presented as mean ± SEM. Significance between groups was determined by Student’s t test, except metabolic data of heat was analyzed by ANCOVA with body weight as a covariate. #P < 0.05 compared CON with NAR.