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Table 2 List of clinical trials investigating the effect of CLA consumption on body composition; ↑- increased; ↓- decreased; ↔ no change in

From: Pros and cons of CLA consumption: an insight from clinical evidences

Subjects Body type Age BMI kg/m 2 Dosage (g/d) Composition Placebo Duration Measurement Effect of CLA Country/State Reference
60 Overweight/obese    1.7, 3.4, 5.1 or 6.8 9 and 10-CLA (50:50) Olive oil 12 wk Dual-energy X-ray absorptiometry ↓ bodyfat mass Norway [36]
54 Overweight 20-50 27.81 ± 1.5 1.8 or 3.6 Tonalin™ OA 13 wk Hydrodensitometry/deuterium dilution ↑ body weight maintenance after weight loss The Netherlands [37]
17 Normal 20-41 - 3 CLA Pharmanutrients Inc. Sunflower oil 64 d Dual x-ray absorptiometry (DXA) ↔ body weight The USA [38]
60 Overweight/obese >18 27.5-39.0 3.4 Tonalin™ Olive oil 12 wk bioelectrical impedance, Dual x-ray absorptiometry ↓ Mean body weight & BMI Norway [39]
48 Normal/obese 18-50 30-35 3.2 or 6.4 9 & 10-CLA (50:50) Safflower oil 12 wk Dual-energy X-ray absorptiometry ↑ LBM The USA [40]
24 Normal 19–24 >30 0.7-1.4 9 & 10-CLA (50:50) Soybean oil 8 wk Skinfold thickness ↓ bodyfat mass - [25]
20 Normal 18-30 >25 1.8 Tonalin™ Hydrogel 12 wk Near infrared light utilizing a Futrex 5000 A instrument ↓ body fat ↔ body weight Norway [41]
23 Normal    3 Tonalin™ Olive oil 28 d Dual-energy X-ray absorptiometry ↔ fat mass The USA [42]
30 Overweight/obese 35-55 >25 3.2 Tonalin™ Safflower oil 12 wk Computed tomography ↔ visceral adipose tissue The USA [22]
118 Overweight/obese 18-65 28–32 3.4 Clarinol™ Olive oil 6 mnt Waist–hip ratio ↓ bodyfat mass Norway [43]
85 Overweight/obese 45-68 25–35 4.5 Tonalin TG 80 Safflower/olive oil 4 wk Waist/hip ratio ↓ body weight Germany [44]
32 Normal    1.3 naturally or synthetically with 9 & 10-CLA Untreated milk 8 wk Magnetic resonance imaging ↔ fat mass Canada [45]
81 overweight 35-65 25-30 1.5/3 Dairy drink with 9 & 10-CLA OA/ sunflower oil 18 wk Dual-energy X-ray absorptiometry ↔ body composition The Netherlands [46]
60 overweight 35-65 25–35 3 Milk with 9 & 10-CLA Skimmed milk 12 wk Dual-energy X-ray absorptiometry ↓ body fat mass Spain [47]
55 Obese ≤70 >30 8 CLA mixture Safflower oil 36 wk Anthropometry ↔ BMI; ↑ lean mass The USA [20]
76 Normal 18 - 45 - 5 Tonalin Sunflower oil 14 wk Air displacement plethysmography ↑ lean tissue mas;↓ body fat mass Canada [48]
81 Postmenopausal women >35   4.7 9 & 10-CLA (50:50) Olive oil 8 wk Dual energy X-ray absorptiometry ↓ total fat mass and lower body fat mass Denmark [49]
33 Type-2 diabetes patients 35-50 25-30 8 9 & 10-CLA (50:50) Soybean oil 8 wk Bioelectrical impedance, anthropometry ↔ body composition Iran [50]