Pros and cons of CLA consumption: an insight from clinical evidences

Nutrition & Metabolism

Table 4 Major clinical trials investigating the effect of CLA consumption on immune status; ↑- increased; ↓- decreased; ↔ no change in

Subjects	Dose	Duration	Observation	Reference
17 women	3.9 g CLA (Tonalin)/d	93 d	↔ immune status	[104]
17 women	3.9 g CLA (Tonalin)/d	93 d	↑ PBMC	[105]
17 women	3.9 g CLA (Tonalin)/d	93 d	↔ circulatory cytokines	[105]
71 males	1.7 g 9 & 10-CLA (50:50), Clarinol™/d	12 wk	↑ protective antibodies upon vaccination for hepatitis B	[106]
49 healthy men	2.38 g/d 9-CLA or	8 wk	↓ mitogen-induced T-lymphocyte activation	[93]
49 healthy men	2.52 g/d 10-CLA	8 wk	↔ circulatory cytokines	[93]
55 healthy volunteers	2 g 9 & 10-CLA (50:50)/d or	8 wk	↔ markers of human immune function	[107]
55 healthy volunteers	1.76 g 9 & 10-CLA (80:20)/d	8 wk	↔ markers of human immune function	[107]
28 men and women	3 g 9 & 10-CLA (50:50)/d	12 wk	↑ levels of IgA, IgM and IL-10	[108]
28 men and women	3 g 9 & 10-CLA (50:50)/d	12 wk	↓ TNF-α, IL-1β and delayed type hypersensitivity response	[108]
28 mild asthmatic adults	4.5 g CLA/d	12 wk	↑ airway hyperresponsiveness	[109]

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