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Table 1 Selected hepatic PPARα regulated genes with at least one functional peroxisome proliferator receptor element (PPRE) identified within the promoter sequence

From: Transcriptional regulation of lipid metabolism by fatty acids: a key determinant of pancreatic β-cell function

Gene Function Species References
Acyl CoA binding protein fatty acyl-CoA ester transport rat 127
Acyl CoA oxidase peroxisomal β-oxidation rat, human 128-130
Apolipoprotein-AI and AII plasma HDL metabolism human, mouse, rat 131-134
Apolipoprotein-AV plasma triglyceride metabolism human 134
Apolipoprotein-CIII plasma HDL metabolism rat 135
Bifunctional enzyme peroxisomal β-oxidation rat 136
Carnitine palmitoyl transferase-I and -II mitochondrial β-oxidation human, mouse, rat, hamster 132, 137-139
Cytochrome P450 enzymes fatty acid and cholesterol metabolism rat, mouse, human 130, 141-145
Δ6- and Δ5-desaturase desaturation of fatty acyl-CoA mouse 146
Fatty acid binding protein fatty acid binding/transport mouse 147
Fatty acid transport protein and translocase fatty acid transport mouse 148, 149
Lipoprotein lipase triglyceride clearance mouse 148, 149
Liver X receptor α cholesterol metabolism mouse 150, 151
Long-chain acyl-CoA synthetase fatty acid activation human, mouse 139, 152
Malic enzyme fatty acid synthesis mouse, rat 153, 154
Mitochondrial HMG-CoA synthase ketogenesis rat, human 152, 155
Medium-chain acyl-CoA dehydrogenase mitochondrial β-oxidation mouse 138, 139
Phospholipid transfer protein HDL metabolism human 156
Stearoyl-CoA desaturase-1 desaturation of fatty acyl CoA mouse 157
Superoxide dismutase free radical metabolism rat 158
Thiolase B mitochondrial β-oxidation rat 159
Transferrin iron transport human 160
Very long- and long-chain acyl CoA dehydrogenases mitochondrial β-oxidation mouse 139
  1. Abbreviations: HDL, high density lipoprotein; HMG-CoA, hydroxymethylglutaryl-Coenzyme A