Age and kidney function are the primary correlates of fasting plasma total homocysteine levels in non-diabetic and diabetic adults. Results from the 1999–2002 National Health and Nutrition Examination Survey

Table 4 Univariate and multivariate linear models predicting total plasma homocysteine among 275 U.S. adults (≥ 20y) with a self-report history of diabetes.

	Sex	Age	HbA_1c	Insulin	BMI	SBP	TC	Folate	B₁₂	S_Cr	C_Cr
1	-0.07	0.0114*	-0.01	-0.00	0.00	0.00	-0.00	-0.00	-0.0004‡	0.0025†
2	-0.1139†	0.0058‡	-0.01	-0.00	0.0154†	0.00	-0.00	-0.00	-0.00		-0.0022†
3	-0.07	0.0094*								0.0021‡
4	-0.0979‡	0.0074†									-0.00

Data are from the combined 1999–2000 and 2001–2002 National Health and Nutrition Examination Surveys. Non-standard abbreviations are SBP, systolic blood pressure, TC, total lipoprotein cholesterol, S_Cr, serum creatinine, and C_Cr, estimated creatinine clearance. Values are regression coefficients (β) from univariate and multivariate linear models using log transformed total homocysteine (log tHcy) as the dependent variable. For simplicity, the intercept term was omitted from the table but was significant (P ≤ 0.0001) in all models. Female sex was used as the reference group.
*P < 0.0001
† P < 0.01
‡ P < 0.05

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