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Table 2 Dose-responsive effect of BW-755c on hypertriglyceridenia in HFF rats

From: Reversal of High dietary fructose-induced PPARα suppression by oral administration of lipoxygenase/cyclooxygenase inhibitors

 

HFF Day 15 n = 24

Vehicle n = 4

5 mg/kg BW (b.i.d.) n = 4

10 mg/kg BW (b.i.d.) n = 4

20 mg/kg BW (b.i.d.) n = 4

50 mg/kg BW (b.i.d.) n = 4

50 mg/kg BW (q.d.) n = 4

Weight (g)

301 ± 2.3

312 ± 8a

312 ± 7a

312 ± 5d

310 ± 5a

316 ± 6b

317 ± 6c

Glucose (mg/dl)

116.0 ± 1.6

113.0 ± 3.4

113.8 ± 6.4

115.3 ± 5.1

112.8 ± 2.9

115.5 ± 8.7

119.3 ± 7.0

Insulin (ng/ml)

1.84 ± 0.06

1.78 ± 0.13

1.83 ± 0.13

1.86 ± 0.15

1.77 ± 0.09

1.82 ± 0.05

1.81 ± 0.13

FFA (μEq/l)

532 ± 17

553 ± 54

552 ± 63

543 ± 92

528 ± 32

562 ± 39

540 ± 52

Cholesterol (mg/dl)

109.6 ± 1.5

106.8 ± 5.8

109.5 ± 6.4

105.0 ± 3.5

107.8 ± 2.8

109.0 ± 4.1

113.3 ± 3.2

TG (mg/dl)

367 ± 16

351 ± 31

319 ± 59

268 ± 18

216 ± 17a

154 ± 33a

215 ± 39a

  1. Results are Mean ± SE
  2. ap < 0.001; bp < 0.002; cp < 0.004; dp < 0.04