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Table 2 Dose-responsive effect of BW-755c on hypertriglyceridenia in HFF rats

From: Reversal of High dietary fructose-induced PPARα suppression by oral administration of lipoxygenase/cyclooxygenase inhibitors

  HFF Day 15 n = 24 Vehicle n = 4 5 mg/kg BW (b.i.d.) n = 4 10 mg/kg BW (b.i.d.) n = 4 20 mg/kg BW (b.i.d.) n = 4 50 mg/kg BW (b.i.d.) n = 4 50 mg/kg BW (q.d.) n = 4
Weight (g) 301 ± 2.3 312 ± 8a 312 ± 7a 312 ± 5d 310 ± 5a 316 ± 6b 317 ± 6c
Glucose (mg/dl) 116.0 ± 1.6 113.0 ± 3.4 113.8 ± 6.4 115.3 ± 5.1 112.8 ± 2.9 115.5 ± 8.7 119.3 ± 7.0
Insulin (ng/ml) 1.84 ± 0.06 1.78 ± 0.13 1.83 ± 0.13 1.86 ± 0.15 1.77 ± 0.09 1.82 ± 0.05 1.81 ± 0.13
FFA (μEq/l) 532 ± 17 553 ± 54 552 ± 63 543 ± 92 528 ± 32 562 ± 39 540 ± 52
Cholesterol (mg/dl) 109.6 ± 1.5 106.8 ± 5.8 109.5 ± 6.4 105.0 ± 3.5 107.8 ± 2.8 109.0 ± 4.1 113.3 ± 3.2
TG (mg/dl) 367 ± 16 351 ± 31 319 ± 59 268 ± 18 216 ± 17a 154 ± 33a 215 ± 39a
  1. Results are Mean ± SE
  2. ap < 0.001; bp < 0.002; cp < 0.004; dp < 0.04