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Table 2 Mendelian causes of type 2 diabetes and obesity

From: Prevalence, predisposition and prevention of type II diabetes

Type 2 diabetes

  

Mutations

Gene Names

Reference

ABCG8

ATP-binding cassette Subunit C

[97, 98]

CAPN10

Calpain 10

[99, 100]

GCGR

Glucagon receptor

[101]

GCK

Glucokinase

[102]

KCNJ11

Potassium channel subunit J, member 11

[103]

PPARG

Peroxisome proliferator-activated receptor γ

[104]

HNF4A

Hepatocyte nuclear factor 4α

[105]

HNF1A

Hepatocyte nuclear factor 1α

[106]

SLC2A1

Glut 1

[107]

INS

Insulin

[108]

INSR

Insulin receptor

[109, 110]

Mitochondrial genome

Mitochondrial DNA

[111]

Obesity

  

Diabetes

Leptin receptor

[112]

Mc4r

Melanocortin-4 receptor

[113]

Obese

Leptin

[114]

PCSK1

Prohormone convertase 1

[115]

Pomc

Pro-opiomelanocortin

[116]

SLC6A14

Solute carrier family 6 member 14

[117]