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Table 2 Mendelian causes of type 2 diabetes and obesity

From: Prevalence, predisposition and prevention of type II diabetes

Type 2 diabetes   
Mutations Gene Names Reference
ABCG8 ATP-binding cassette Subunit C [97, 98]
CAPN10 Calpain 10 [99, 100]
GCGR Glucagon receptor [101]
GCK Glucokinase [102]
KCNJ11 Potassium channel subunit J, member 11 [103]
PPARG Peroxisome proliferator-activated receptor γ [104]
HNF4A Hepatocyte nuclear factor 4α [105]
HNF1A Hepatocyte nuclear factor 1α [106]
SLC2A1 Glut 1 [107]
INS Insulin [108]
INSR Insulin receptor [109, 110]
Mitochondrial genome Mitochondrial DNA [111]
Obesity   
Diabetes Leptin receptor [112]
Mc4r Melanocortin-4 receptor [113]
Obese Leptin [114]
PCSK1 Prohormone convertase 1 [115]
Pomc Pro-opiomelanocortin [116]
SLC6A14 Solute carrier family 6 member 14 [117]