Table 3 Potential therapies for the prevention of type 2 diabetes.
From: Prevalence, predisposition and prevention of type II diabetes
Non-pharmaceutical Approach | |||
|---|---|---|---|
Method | Â | Clinically Proven | |
Lifestyle modification | Â | yes | |
Bariatric surgery | Â | yes | |
Pharmaceutical Approach | |||
Drugs | Molecular Target | Site(s) of Action | Clinically Proven |
Metformin | Unknown | Liver (muscle) | Yes |
Acarbose | α-glucosidase | Intestine | Yes |
Olistat | lipase | Intestine | Yes |
Thiazolidinediones | PPARγ | Liver, fat, muscle | Yes |
Rimonobant | CB-1 | Brain (fat, liver) | No |
DPP4 inhibitors | DPP4 | pancreatic islet beta-cells | No |
GLP1 analogs | GLP1-receptor | pancreatic islet beta-cells | No |