Characterization of the PEPCK-C-/- mice. Panel A. A representative Northern blot for mRNA isolated from the liver and kidney of two-day-old mice. Panel B. PEPCK-C activity was determined in the livers of two-day-old mice. The results are expressed as the mean ± S.E. for three animals in each group. Panel C. Photograph of two-day-old PEPCK-C-/- mice. Panel D. Growth retardation of PEPCK-C-/- mice. Body weights of neonates were measure at 6, 30, and 37 h after birth. Three wild type mice and three PEPCK-C-/- mice were used.