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Figure 6 | Nutrition & Metabolism

Figure 6

From: Effect of food deprivation and hormones of glucose homeostasis on the acetyl CoA carboxylase activity in mouse brain: a potential role of acc in the regulation of energy balance

Figure 6

Hypothesis of Neurohormonal Signalling During Deprivation. Upon food deprivation, glucagon reaches a threshold level to activate the ACC-kinase. ACC-kinase phosphorylates ACC making it a less active citrate dependent species. Due to less active ACC, malonyl CoA levels drop, resulting in increased NPY expression. NPY subsequently promotes feeding.

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