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Table 2 Observational Studies of Stearic Acid and Cardiovascular Outcomes

From: Chocolate and Prevention of Cardiovascular Disease: A Systematic Review

Author Year Study design N, Population Stearic acid assessment method CHD/MI Outcomes Other
Kromhout [141] 1995 Ecologic 12,763 men, 16 cohorts of 7CS Dietary intake ↑ CHD mortality  
Simon [68, 69] 1995 Prospective 96 cases, 96 controls, USA-MRFIT Serum levels ↑ CHD incidence Null-stroke incidence
Watts [67] 1996 Prospective 50 men, Australia Dietary intake ↑ CAD progression  
Hojo [61] 1998 Case-control 71 cases, 60 controls, Japan Serum levels   Null-stenosis
Hu [65] 1999 Prospective 80,082 women, USA-nurses Dietary intake ↑ CHD incidence  
Yli-Jama [62] 2002 Case-control 103 cases, 104 controls, Norway Serum levels ↓ MI incidence  
Kabagambe [63] 2003 Case-control 485 cases, 508 controls, Costa Rica Dietary intake ↑ MI incidence  
Wang [66] 2003 Prospective 3591 whites, USA Serum levels ↑ CHD mortality  
  1. Abbreviations: 7CS, 7 Countries Study; MRFIT, Multiple Risk Factor Intervention Trial;
  2. * High stearic acid level among men from geographic areas of high IHD mortality