Short-term arginine deprivation results in large-scale modulation of hepatic gene expression in both normal and tumor cells: microarray bioinformatic analysis

Table 1 Microarray Suite analysis of gene regulation in normal vs. tumor cells in response to 18 hr arginine deprivation.

CODE	CELL TYPE	ARG STATUS	ABSENT	PRESENT	NET INCREASE	NET DECREASE	MARGINAL	NO CHANGE
N1	NORMAL	Arg +	7189	8474
N3	"	Arg +	7102	8536
N5	"	Arg +	7010	8662
N2	"	Arg deficient	7140	8532	1242	876	135	6221
N4	"	Arg deficient	7296	8381	358	136	52	7990
N6	"	Arg deficient	6601	9082	832	811	105	6914
MEAN	Normal		7106	8611	811	608	97	7042
AVEDEV			167	174	302	314	30	632
T1	TUMOR	Arg +	7085	8535
T3	"	Arg +	7051	8607
T5	"	Arg +	7423	8224
T2	"	Arg deficient	6934	8725	1514	1187	119	5715
T4	"	Arg deficient	7664	7973	1391	913	117	6186
T6	"	Arg deficient	7573	8065	843	678	86	6617
MEAN	Tumor		7288	8355	1249	926	109	6173
AVEDEV			265	268	271	174	14	305

Numbers of rat genes in Affymetrix RAE 230 array demonstrating expression, no change, increase, decrease and marginal change. Change in gene expression based on p value of 0.05 or less in pair-wise comparisons of three independent datasets. RAE 230 array contains 15,923 genes.

ISSN: 1743-7075