diets | CRF-1 | OA-2 |
---|
Genotype and sex age | 6 months | 12 months | 6 months | 12 months |
Male wild-type | 0/8 | 0/20 | 3/22 | 2/9* |
Male CCK-1R(-/-) | 0/20 | 3/8† # | 5/18* | 13/18† # |
Female wild-type | 0/9 | 1/16 | 0/8 | 1/11 |
Female CCK-1R(-/-) | 0/9 | 4/9†# | 1/10 | 9/15† # |
- Values are means ± SE. The frequencies of sludge and gallstone formation represent the number of sludge and gallstone formations/the number of animals examined. *, significantly different from the value of the corresponding CRF-1 fed mice; †, significantly higher than the respective values at 6 months of age; and #, significantly different from the value of wild-type mice. The results of statistical analyses are shown in the text.