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Table 2 Frequencies of sludge and gallstone formation in 6- and 12-month-old male and female mice

From: Susceptibility to obesity and gallbladder stasis produced by a protein- and fat-enriched diet in male mice compared with female mice

diets

CRF-1

OA-2

Genotype and sex age

6 months

12 months

6 months

12 months

Male wild-type

0/8

0/20

3/22

2/9*

Male CCK-1R(-/-)

0/20

3/8† #

5/18*

13/18† #

Female wild-type

0/9

1/16

0/8

1/11

Female CCK-1R(-/-)

0/9

4/9†#

1/10

9/15† #

  1. Values are means ± SE. The frequencies of sludge and gallstone formation represent the number of sludge and gallstone formations/the number of animals examined. *, significantly different from the value of the corresponding CRF-1 fed mice; †, significantly higher than the respective values at 6 months of age; and #, significantly different from the value of wild-type mice. The results of statistical analyses are shown in the text.