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Table 2 Frequencies of sludge and gallstone formation in 6- and 12-month-old male and female mice

From: Susceptibility to obesity and gallbladder stasis produced by a protein- and fat-enriched diet in male mice compared with female mice

diets CRF-1 OA-2
Genotype and sex age 6 months 12 months 6 months 12 months
Male wild-type 0/8 0/20 3/22 2/9*
Male CCK-1R(-/-) 0/20 3/8† # 5/18* 13/18† #
Female wild-type 0/9 1/16 0/8 1/11
Female CCK-1R(-/-) 0/9 4/9†# 1/10 9/15† #
  1. Values are means ± SE. The frequencies of sludge and gallstone formation represent the number of sludge and gallstone formations/the number of animals examined. *, significantly different from the value of the corresponding CRF-1 fed mice; †, significantly higher than the respective values at 6 months of age; and #, significantly different from the value of wild-type mice. The results of statistical analyses are shown in the text.