Bio F1B hamster: a unique animal model with reduced lipoprotein lipase activity to investigate nutrient mediated regulation of lipoprotein metabolism

Table 3 Very-low-density lipoprotein (VLDL) lipid concentrations for F₁B and Golden Syrian (GS) hamsters

VLDL	Diet	Animal Strain		Statistical Analysis
(mmol/L)		F1B	GS	Interaction	P value
Cholesterol	FO	8.33 ± 1.57	2.63 ± 0.48	D × S	P = 0.0007
	MUFA	1.20 ± 0.21	0.12 ± 0.04	D	P < 0.0001
	N6:N3	1.47 ± 0.26	0.50 ± 0.17	S	P < 0.0001
Triglycerides	FO	25.3 ± 8.82	1.31 ± 0.55	D × S	P = 0.0015
	MUFA	4.11 ± 1.26	0.73 ± 0.25	D	P = 0.0014
	N6:N3	4.28 ± 1.81	1.68 ± 0.31	S	P = 0.0003
Free Cholesterol	FO	5.03 ± 1.04	0.12 ± 0.03	D × S	P < 0.0001
	MUFA	0.64 ± 0.21	0.05 ± 0.01	D	P < 0.0001
	N6:N3	1.07 ± 0.63	0.17 ± 0.06	S	P < 0.0001
Cholesterol Esters	FO	3.31 ± 0.55	1.32 ± 0.28	D	P < 0.0001
	MUFA	0.57 ± 0.18	0.09 ± 0.03	S	P < 0.0001
	N6:N3	1.91 ± 0.81	0.33 ± 0.12

Hamsters were fed fish oil (FO), monounsaturated fatty acid rich (MUFA) or N6:N3 diets for 4 weeks. Lipids were analysed as described under materials and methods section. Values are means SEM, (n = 6 for F1B, n = 6 for GS). Groups were compared by two-way ANOVA, p = 0.05. D, S represents diet and strain respectively.

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