Bio F1B hamster: a unique animal model with reduced lipoprotein lipase activity to investigate nutrient mediated regulation of lipoprotein metabolism

Table 4 Low-density lipoprotein (LDL) lipid concentrations for F₁B and Golden Syrian (GS) hamsters

LDL	Diet	Animal Strain		Statistical Analysis
(mmol/L)		F1B	GS	Interaction	P value
Cholesterol	FO	7.18 ± 2.39	2.54 ± 0.10	D	P = 0.0006
	MUFA	1.55 ± 0.19	0.67 ± 0.07	S	P = 0.0004
	N6:N3	3.92 ± 0.56	0.95 ± 0.10
Triglycerides	FO	12.1 ± 4.58	3.06 ± 0.44	D × S	P = 0.0118
	MUFA	0.19 ± 0.05	0.24 ± 0.08	D	P < 0.0001
	N6:N3	0.44 ± 0.23	0.58 ± 0.14	S	P = 0.0348
Free Cholesterol	FO	1.71 ± 0.28	1.10 ± 0.04	D	P < 0.0001
	MUFA	0.76 ± 0.24	0.23 ± 0.02	S	P = 0.0005
	N6:N3	0.98 ± 0.36	0.41 ± 0.02
Cholesterol Esters	FO	1.64 ± 0.30	1.10 ± 0.04	D × S	P = 0.0005
	MUFA	1.15 ± 0.26	0.23 ± 0.02	D	P = 0.001
	N6:N3	2.93 ± 0.35	0.41 ± 0.02		P = 0.0003

Hamsters were fed fish oil (FO), monounsaturated fatty acid rich (MUFA) or N6:N3 diets for 4 weeks. Lipids were analysed as described under materials and methods section. Values are means SEM, (n = 6 for F1B, n = 6 for GS). Groups were compared by two-way ANOVA, p = 0.05. D, S represents diet and strain respectively.

ISSN: 1743-7075